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AGA and Stem Cell Therapy

The most common cause of hair loss is androgenetic alopecia (AGA)

In recent years, new treatments for hair loss have expanded to include hair tissue engineering and stem cells

Document DOI: 10.

The root cause of androgenic alopecia (AGA) is believed to be a congenital defect in the structure of the hair follicles on the top of the head, which degenerates and shrinks, causing the hair to become thinner, thinner and softer

In this study, the researchers selected adipocyte tissue as a source of mesenchymal stem cells (MSCs) with the potential for multidirectional isolation

Previous in vitro studies have shown that ADSC-CM affects human dermal papilla cells (DPC) by enhancing and activating ERK and AKT signaling pathways

In addition, ADSCs can secrete various cytokines and growth factors that are beneficial for hair growth, including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and insulin-like growth.

30 patients participated in stem cell therapy experimental study

The researchers first assessed the effect of ADSC-CM on hair density and volume by standardizing digital photography and photogrammetry in 30 patients with alopecia by non-ablative fractional laser treatment with ADSC-CM or a placebo solution

Mean hair density measured at weeks 0, 4, 8 and 12 in placebo and adipose-derived stem cell conditioned medium (ADSC-CM) groups

Based on the comparison of hair density during the treatment period, the results showed that the ADSC-CM group had significantly higher hair density compared to the placebo group

Examples of global photographs taken at baseline (A) and at week 12 (B) in patients treated with adipose-derived stem cell conditioned medium (ADSC-CM)

Summary and Outlook

Overall, this study is the first clinical randomized placebo-controlled trial to analyze the effect of topical ADSC-CM on alopecia

Finally, here are some tips to effectively prevent hair loss in your daily life:

Refuse to stay up late and avoid mental stress;

Get enough protein and vitamins;

Carefully take care of your hair and reduce the frequency of perming and dyeing

References:

[1] https://journals.