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The infectious fungus Cryptococcus neoformans rapidly grow or shrink in size to defend against different microenvironments
According to the latest research by scientists at the University of Utah Health Center, a fungus is a common cause of fungal meningitis, and once it enters the human body, it undergoes a significant shift that infects the brain
This finding may lead to new blocking strategies
"Cryptococcus has a wide variety of cells in the lungs, varying
This fungus can quickly adapt to the microenvironment in the body
Brown has observed fungi thriving in many different habitats
Previously, other scientists have found that the fungus copes with life in the lungs by growing to 10 times its normal size, possibly because the host's immune system cannot be destroyed
To find out, her team used c.
The evidence suggests that the small fungal cells that Brown calls "seed" cells aren't just miniature versions
After searching for triggers, Brown's team discovered a special chemical — phosphate — that can induce this shift
From guano to the brain
Curiously, the fungus's ability to effectively target the brain may stem from a unique source: bird droppings
Brown thinks this could demonstrate how the pathogenicity of this fungus was initially produced
Regardless of how the fungus is contagious, the team is now trying to block this ability
A dissemination-prone morphotype enhances extrapulmonary organ entry by the fungus Cryptococcus neoformans
