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In a new study led by the University of Buffalo, scientists have proposed a new role for the huntingtin protein (HTT), which causes Huntington's disease
when mutated.
The team led by UB biologist Shermali Gunawardena has long studied HTT and its basic function
in neuronal cells.
A new study builds on past work to describe in detail HTT's unknown role in cell compartments moving in the direction of the nucleus
.
"We found that HTT is packaged in different types of mobile goods within the cell, and it is involved in so many processes
.
In the new paper, "we found that the huntingtin protein is involved in neuronal damage processes," Gunavardner said
.
Video:_msthash="320079" _msttexthash="72734727">Experiments have shown that this HTT packet may carry signaling molecules that are "essential for activating the production of proteins needed for neuronal regeneration," Gunawardena said
.
The study was published in the Sept.
"While many studies have looked at the disease mechanisms of HTT in Huntington's disease, here we focus on studying the fundamental role
of HTT in neurons.
Krzystek said: "We knew for decades that neurons in the central nervous system are less
able to regenerate after axonal injury.
The study was funded by the National Institute of Neurological Disorders and Stroke and the BrightFocus Foundation under the National Institutes
of Health.
