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On November 30, Tianyan Pharmaceuticals announced that the US FDA has approved its Phase 1b/2 clinical trial application for the combination therapy of its anti-CTLA-4 monoclonal antibody (mAb) ADG116 and anti-PD-1 antibody pembrolizumab
CTLA-4 and PD-1 are considered to be two important checkpoint proteins of the immune system.