Thyroid: Ultrasound tests can reveal salivary gland damage in patients with thyroid papilloma stoma treatment caused by radioactive iodine treatment

An important side effect for patients with thyroid papilloma (PTC) treated with radioactive iodine 131I (RAI) is chronic salivating adenitisA neck ultrasound (US) makes it easy to identify salivary gland abnormalities caused by radioactive iodineA study published recently in Thyroid, an authoritative journal of thyroid disease, aims to identify the prevalence of salivary dinitilist detected by RAI and to identify risk factors associated with this damagethis non-contemporaneous cohort study included all PTC patients who were treated with RAI from 2007 to 2017 and evaluated for preoperative and follow-up neck US, including targeted profiling of major salivary glandsPatients with salivary gland disease were excludedThe researchers qualitatively assessed anatomical damage (reduced gland size, wave profile, low echoand, and heterogeneity) and compared it with preoperative studiesThe researchers assessed RAI activity, gender, age, and treatment as risk factors using single- and multi-factor analysis and logistic regressionthe study recruited 570 patients who received a median activity of 3700MBq (100 mCi) for RAIIn the US examination, the researchers found that 143 patients (25.1%) had at least one salivary gland damage: all patients had mumps damage (77 cases on both sides) and 14 cases (9.8%) of jaw gland damage (7 cases on both sides)Multiple studies showed that the risk of salivary dinitienter was significantly associated with RAI activity and gender (p 0.01) (14.1% for men and 28.5% for women)However, the main risk factor for salivating adenitis is RAI activityNo injuries were detected in 156 patients receiving 1110 MBq (30 mCi) and 1850 MBq (50 mCi) RAIIn patients receiving 3700 MBq (100 mCi), 5550 MBq (150 mCi) and .7400 MBq (?200 mCi) RAI, 21%, 46.9% and 77.7% of patients developed salivary gland atrophy, respectivelyAge and treatment were not associated with an increased risk of salivary gland atrophyshows that chronic salivary adenitis is common and affects about a quarter of patients who receive 3700 MBq (100 mCi) or higherThe main risk factor for this injury is the total RAI activity used in treatment Irreversible damage in the salivary glands can be minimized by using the lowest possible effective activity US is a great tool for diagnosing salivary gland atrophy after RAI