This polyphenol in blueberries improves colon inflammation

an RSV-related polyphenol found in blueberries, PSB, has strong immunosuppressive properties.Polyphenols are a natural product of human consumption and are found in many vegetables, fruits and herbs, such as apples, grapes and tea. Grapes are rich in polyphenols, such as resveratrol (RSV). Studies have shown that RSV may play a therapeutic role in neurological, cardiovascular and metabolic diseases in humans. In addition, in mouse colitis models, RSV has been shown to have immunomodulative activity and reduce inflammation.Recently, researchers at the Tokyo University of Science found that an RSV-related polyphenol found in blueberries, PSB (3', 5'--methyl resveratrol), has strong immunosuppressive properties. It can provide potential treatment options for chronic inflammatory diseases, including inflammatory bowel disease (IBD). The results are published in FASEB JOURNAL.Because the body's increased immune response causes chronic inflammation, patients with IBD have persistent ulcers in the gastrointestinal wall. This is associated with excessive cytokine production, as well as protrusion cells (DC) and T-cells. At the beginning of the immune response, DC produces inflammatory cytokines and activates T cells to initiate a defensive response. Together, these processes form complex pathways that lead to an over-immune response.Therefore, it is important to test this immune cell population to find an effective compound that suppresses the immune system.In this study, scientists first studied the effects of compounds from a range of plant sources on DC-mediated T-cell proliferation through an in-body coculture system. They found that of all the resveratrol derivatives tested, PSB played the most inhibitory role in DC-mediated T-cell proliferation.Further studies have shown that PSB treatment prevents T-cell differentiation into Th1 and Th17 populations (T-cell subtypes that improve immune response) and increases their ability to differentiate into regulatory T-cells (another subtype that inhibits inflammation).In addition, PSB processing inhibits DC-producing inflammatory cytokines by reducing the DNA binding activity of the key transcription factor PU.1. Further tests in mice with IBD found that oral PSB improved IBD symptoms. What's more, PSBs are more easily absorbed by the body and therefore have higher bio-utilization than RSV.But there is more than one active ingredient in blueberries, and anthocyanins, anthocyanins, resveratrol, and flax lysate are all bioactive ingredients in blueberries. In addition, blueberries can be distributed to different organs or even across the blood-brain barrier to the brain, coupled with its role in antioxidant, sterilization, as well as diabetes, hyperlipidemia, neurodegeneration, and so on, so it is considered one of the most nutritionally valuable foods.
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