This antibody treatment prevents inflammation of the lungs and nervous system after SARS-CoV-2 infection

A new study by researchers at the University of California, Davis shows that monoclonal antibodies can protect elderly diabetic rhesus monkeys from diseases caused by SARS-CoV-2 and reduce the amount of cerebrospinal fluid Signs of inflammation inside
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The authors say that the data show that neutralizing antibodies can prevent the adverse inflammatory consequences of SARS-CoV-2 infection
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Smita Iyer, associate professor of pathology, microbiology, and immunology at the University of California, Davis School of Veterinary Medicine and Center for Immunity and Infectious Diseases, and core researcher at the California National Primate Research Center, said: "COVID-19 is in the elderly and existing It’s more serious among people with the disease
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"Elderly people and diabetics are often immunosuppressed, but if antibody levels are high enough, serious infections can be prevented," she said
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The immune response caused by the vaccine is very effective in preventing serious illness and death
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Iyer said: "We want to know what are the immune determinants of disease
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Iyer, graduate student Jamin (JW) Roh, postdoctoral scholar Anil Verma, and his colleagues studied two human monoclonal antibodies that target the SARS-CoV-2 virus spike protein in elderly diabetic rhesus monkeys
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Prevent inflammation of the central nervous system

The infection of the new coronavirus in rhesus monkeys is usually mild, especially in animals pretreated with monoclonal antibodies
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The researchers found that one week after the infection, activated immune cells (T cells) were infiltrated in the cerebrospinal fluid of the control animals
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These signs of inflammation in the central nervous system may be related to the neurological symptoms of human COVID-19 disease, or may be related to the "long-term sequelae of COVID", that is, patients experience a series of symptoms several months after infection