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A collaborative study by German and British scientists found that deletion or mutation of the genes RNF43 and ZNRF3 triggers a regulatory signal of lipid metabolism, which in turn leads to lipid accumulation and inflammation in the liver
.
The results of this study may explain why some people are very thin, but still suffer from fatty liver
Previous Cancer Genome studies have identified RNF43 and ZNRF3 as genes that are mutated in colon and liver cancer patients
.
The research team, led by Dr.
The study found that in non-obese mice fed a normal diet, deletion or mutation of the genes RNF43 and ZNRF3 led to lipid accumulation and inflammation in the liver
.
These genetic changes not only lead to an increase in fat accumulation, but also an increase in liver cells
"With organoids, we were able to grow liver cells that were mutated only in these genes, and we saw that the loss of these genes triggered a Regulatory signals
for lipid metabolism.
As a result, lipid metabolism is no longer under control, and lipids accumulate in the liver, which in turn leads to fatty liver
The scientists compared the experimental results with patient data published by the International Cancer Genome Consortium
.
They examined the survival chances of patients with liver cancer when these two genes were mutated and found that patients with these gene mutations had fatty liver disease and had a worse prognosis
