-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
*Only for medical professionals to read for reference.
Be wary of drug-induced dementia
.
September 21, 2021 is the 28th World Alzheimer's Day, and Alzheimer's disease is one of the main types of dementia
.
A new study published in the BMC Journal of Public Health in 2018 stated that another disease related to heavy drinking has been added-dementia
.
The lead author of the study, Dr.
Michael Schwarzinger, believes that it may be the result of permanent structural and functional brain damage caused by alcohol
.
Alcohol also increases the risk of high blood pressure, diabetes, stroke, atrial fibrillation and heart failure, which in turn may increase the risk of vascular dementia
.
Researchers found that in 57,000 cases of early-onset dementia (dementia that occurred before the age of 65), alcohol accounted for 57%
.
Overall, alcoholism increases the risk of all types of dementia by 3 times [1]
.
Except for alcohol abuse, drugs play an important role in the pathogenesis of dementia
.
It is worth noting that because the elderly are prone to frailty and disease, they need to take drugs frequently.
However, some drugs can induce or aggravate the symptoms of senile dementia.
Therefore, we must pay more attention to the use of drugs in clinical practice
.
The following ten types of drugs may induce or aggravate dementia
.
Hurry up and collect it! 1 Drugs that act on the central nervous system: sedative and hypnotics of the central nervous system: limianine, barbiturates, sedative and hypnotic drugs, such as long-term use can cause symptoms of senile dementia, if you use such drugs to treat senile dementia, sometimes it can also cause symptoms of the disease Once addicted, withdrawal is very difficult, and it can cause delirium or disturbance of consciousness during withdrawal; antipsychotic drugs: antipsychotic drugs such as methoxyalimazine, haloperidol, etc.
, can cause disorientation and calculation ability Diminish
.
2 Anti-tremor paralysis drug Anticholinergic drug Benhexyl (Antan), research shows that its anticholinergic effect can cause central anticholinergic syndrome
.
Taking the medicine for too long, the patient's memory of his name and objects is not very clear, and sometimes symptoms such as poor orientation ability; broccotine mesylate, levodopa, etc.
can cause delusions and hallucinations; long-term use of amantadine It can cause emotional apathy, lack of concentration and so on
.
3 The anti-epileptic drugs phenytoin and carbamazepine can inhibit the electrical conduction of the nerve membrane on average, and proper dosage has obvious therapeutic effect on senile epilepsy and epilepsy caused by traumatic brain injury, but overdose or medication for too long will reduce intelligence; Although drugs such as Jingning and Ethosuximide have certain anti-epileptic effects, long-term use can aggravate symptoms of senile dementia, as well as apathy and confusion
.
4.
Anti-anxiety and depression drugs.
Anti-anxiety drugs: anti-anxiety drugs such as Valium, etc.
, regular use will not only cause dependence, but also can induce severe memory loss; antidepressants: tricyclic antidepressants imipramine, amitriptyline It can cause hallucinations and confusion, and induce dementia in patients
.
5 Anti-tumor drugs Antimetabolites used to treat tumors can cause or aggravate forgetfulness and disorientation
.
Such as continuous medication can cause the patient to lethargy, even if the medication is stopped, the symptoms are not easily reversed, and early detection and early discontinuation of the medication must be necessary
.
6 Digestive system medication Cimetidine can inhibit gastric acid secretion and has antihistamine effects, but it can also cause adverse reactions such as delirium, intellectual impairment, and lethargy.
In addition, it has been reported that many patients with Alzheimer's disease have higher levels of aluminum in the brain than normal people.
10~30 times higher
.
Therefore, aluminum-containing antacids (such as magnesium aluminum carbonate chewable tablets) should be eaten as little as possible, and long-term use is contraindicated, because aluminum is neurotoxic and can induce or aggravate dementia in patients
.
7 Cardiovascular system medications blood pressure lowering drugs: such as reserpine, methyldopa, clonidine, etc.
, because it easily crosses the blood-brain barrier, long-term use can cause drowsiness and fatigue by depleting central norepinephrine and serotonin , Mental depression and other reactions, make the nerve function low; after the elderly excessively reduce blood pressure, the cerebral blood flow may be reduced, which aggravates the obstacles of brain function, thereby inducing dementia or aggravating dementia
.
Heart strengthening drugs: Digitalis is used to treat chronic heart insufficiency, paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter, etc.
caused by various reasons.
It is used for chronic congestion with enlarged heart chambers and significantly increased diastolic volume.
The effect of sexual heart failure is better
.
However, in addition to the symptoms of accumulated poisoning, digitalis may also suffer from central nervous system dysfunction such as visual impairment, positioning illusion, and mental decline
.
8 Respiratory system medication The central antitussive aminophylline is used to relieve wheezing symptoms such as bronchial asthma, wheezing bronchitis, obstructive emphysema, and can also be used for heart failure asthma (cardiogenic asthma)
.
However, aminophylline is a "double-edged sword", and general doses can also cause serious poisoning.
This is because theophylline is not fully degraded, except for common tremor, dizziness, anxiety, agitation, insomnia, visual disturbances, and seizures.
It can also induce depression, confusion and toxic psychosis
.
9 Antipyretic, anti-inflammatory and analgesics such as indomethacin can cause emotional apathy; analgesics can cause delusions and confusion
.
10 Vitamins and irons.
Taking too much vitamin D can aggravate the disturbance of consciousness in patients with dementia; vitamin B12 is required for the development of the central nervous system.
If vitamin B12 deficiency or B12 malabsorption, it may cause the patients to suffer from mental decline, abnormal orientation and other central nervous systems.
Neurological dysfunction; in addition, studies have found that there is excessive iron accumulation in the brains of patients with Alzheimer's disease
.
The content of iron in the brain can increase with age, especially for the elderly.
Iron supplementation from food should be emphasized during anemia.
Iron supplementation can only be done under the guidance of a doctor in the case of severe iron deficiency
.
The above ten drugs may induce or aggravate senile dementia, but it does not necessarily induce or aggravate dementia in patients.
Because of the possibility, we must be vigilant when applying related drugs in clinical practice.
For frail and sickly elderly people, because of the complexity of taking drugs, we should be more cautious.
When other drugs can be used instead of treatment, we should try not to use the above drugs as much as possible, and the indications should be strictly controlled when taking the drugs, and the dose should be gradually increased from the minimum dose.
In the course of use, carefully observe the patient's reaction.
When relevant adverse reactions occur, the drug should be discontinued immediately and treated in time
.
Summary table of the top ten drugs that can induce dementia References: [1]Schwarzinger M, Thiébaut SP, Baillot S, Mallet V, Rehm J.
Alcohol use disorders and associated chronic disease-a national retrospective cohort study from France[published correction appears in BMC Public Health.
2017 Sep 22;17(1):736].
BMC Public Health.
2017;18(1):43.
Published 2017 Jul 21.
doi:10.
1186/s12889-017-4587-y.
[2].
Beware of drugs that induce or aggravate the symptoms of Alzheimer’s[N].
China Medical News,2012-11-07(007).
[3]Wang Sudan.
Drugs that can induce or aggravate Alzheimer’s disease[J].
Health for Everyone,1999 ,09:20.
[4].
Beware of drug-induced senile dementia[J].
Chinese People's Liberation Army Health,2012,04:34.
Be wary of drug-induced dementia
.
September 21, 2021 is the 28th World Alzheimer's Day, and Alzheimer's disease is one of the main types of dementia
.
A new study published in the BMC Journal of Public Health in 2018 stated that another disease related to heavy drinking has been added-dementia
.
The lead author of the study, Dr.
Michael Schwarzinger, believes that it may be the result of permanent structural and functional brain damage caused by alcohol
.
Alcohol also increases the risk of high blood pressure, diabetes, stroke, atrial fibrillation and heart failure, which in turn may increase the risk of vascular dementia
.
Researchers found that in 57,000 cases of early-onset dementia (dementia that occurred before the age of 65), alcohol accounted for 57%
.
Overall, alcoholism increases the risk of all types of dementia by 3 times [1]
.
Except for alcohol abuse, drugs play an important role in the pathogenesis of dementia
.
It is worth noting that because the elderly are prone to frailty and disease, they need to take drugs frequently.
However, some drugs can induce or aggravate the symptoms of senile dementia.
Therefore, we must pay more attention to the use of drugs in clinical practice
.
The following ten types of drugs may induce or aggravate dementia
.
Hurry up and collect it! 1 Drugs that act on the central nervous system: sedative and hypnotics of the central nervous system: limianine, barbiturates, sedative and hypnotic drugs, such as long-term use can cause symptoms of senile dementia, if you use such drugs to treat senile dementia, sometimes it can also cause symptoms of the disease Once addicted, withdrawal is very difficult, and it can cause delirium or disturbance of consciousness during withdrawal; antipsychotic drugs: antipsychotic drugs such as methoxyalimazine, haloperidol, etc.
, can cause disorientation and calculation ability Diminish
.
2 Anti-tremor paralysis drug Anticholinergic drug Benhexyl (Antan), research shows that its anticholinergic effect can cause central anticholinergic syndrome
.
Taking the medicine for too long, the patient's memory of his name and objects is not very clear, and sometimes symptoms such as poor orientation ability; broccotine mesylate, levodopa, etc.
can cause delusions and hallucinations; long-term use of amantadine It can cause emotional apathy, lack of concentration and so on
.
3 The anti-epileptic drugs phenytoin and carbamazepine can inhibit the electrical conduction of the nerve membrane on average, and proper dosage has obvious therapeutic effect on senile epilepsy and epilepsy caused by traumatic brain injury, but overdose or medication for too long will reduce intelligence; Although drugs such as Jingning and Ethosuximide have certain anti-epileptic effects, long-term use can aggravate symptoms of senile dementia, as well as apathy and confusion
.
4.
Anti-anxiety and depression drugs.
Anti-anxiety drugs: anti-anxiety drugs such as Valium, etc.
, regular use will not only cause dependence, but also can induce severe memory loss; antidepressants: tricyclic antidepressants imipramine, amitriptyline It can cause hallucinations and confusion, and induce dementia in patients
.
5 Anti-tumor drugs Antimetabolites used to treat tumors can cause or aggravate forgetfulness and disorientation
.
Such as continuous medication can cause the patient to lethargy, even if the medication is stopped, the symptoms are not easily reversed, and early detection and early discontinuation of the medication must be necessary
.
6 Digestive system medication Cimetidine can inhibit gastric acid secretion and has antihistamine effects, but it can also cause adverse reactions such as delirium, intellectual impairment, and lethargy.
In addition, it has been reported that many patients with Alzheimer's disease have higher levels of aluminum in the brain than normal people.
10~30 times higher
.
Therefore, aluminum-containing antacids (such as magnesium aluminum carbonate chewable tablets) should be eaten as little as possible, and long-term use is contraindicated, because aluminum is neurotoxic and can induce or aggravate dementia in patients
.
7 Cardiovascular system medications blood pressure lowering drugs: such as reserpine, methyldopa, clonidine, etc.
, because it easily crosses the blood-brain barrier, long-term use can cause drowsiness and fatigue by depleting central norepinephrine and serotonin , Mental depression and other reactions, make the nerve function low; after the elderly excessively reduce blood pressure, the cerebral blood flow may be reduced, which aggravates the obstacles of brain function, thereby inducing dementia or aggravating dementia
.
Heart strengthening drugs: Digitalis is used to treat chronic heart insufficiency, paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter, etc.
caused by various reasons.
It is used for chronic congestion with enlarged heart chambers and significantly increased diastolic volume.
The effect of sexual heart failure is better
.
However, in addition to the symptoms of accumulated poisoning, digitalis may also suffer from central nervous system dysfunction such as visual impairment, positioning illusion, and mental decline
.
8 Respiratory system medication The central antitussive aminophylline is used to relieve wheezing symptoms such as bronchial asthma, wheezing bronchitis, obstructive emphysema, and can also be used for heart failure asthma (cardiogenic asthma)
.
However, aminophylline is a "double-edged sword", and general doses can also cause serious poisoning.
This is because theophylline is not fully degraded, except for common tremor, dizziness, anxiety, agitation, insomnia, visual disturbances, and seizures.
It can also induce depression, confusion and toxic psychosis
.
9 Antipyretic, anti-inflammatory and analgesics such as indomethacin can cause emotional apathy; analgesics can cause delusions and confusion
.
10 Vitamins and irons.
Taking too much vitamin D can aggravate the disturbance of consciousness in patients with dementia; vitamin B12 is required for the development of the central nervous system.
If vitamin B12 deficiency or B12 malabsorption, it may cause the patients to suffer from mental decline, abnormal orientation and other central nervous systems.
Neurological dysfunction; in addition, studies have found that there is excessive iron accumulation in the brains of patients with Alzheimer's disease
.
The content of iron in the brain can increase with age, especially for the elderly.
Iron supplementation from food should be emphasized during anemia.
Iron supplementation can only be done under the guidance of a doctor in the case of severe iron deficiency
.
The above ten drugs may induce or aggravate senile dementia, but it does not necessarily induce or aggravate dementia in patients.
Because of the possibility, we must be vigilant when applying related drugs in clinical practice.
For frail and sickly elderly people, because of the complexity of taking drugs, we should be more cautious.
When other drugs can be used instead of treatment, we should try not to use the above drugs as much as possible, and the indications should be strictly controlled when taking the drugs, and the dose should be gradually increased from the minimum dose.
In the course of use, carefully observe the patient's reaction.
When relevant adverse reactions occur, the drug should be discontinued immediately and treated in time
.
Summary table of the top ten drugs that can induce dementia References: [1]Schwarzinger M, Thiébaut SP, Baillot S, Mallet V, Rehm J.
Alcohol use disorders and associated chronic disease-a national retrospective cohort study from France[published correction appears in BMC Public Health.
2017 Sep 22;17(1):736].
BMC Public Health.
2017;18(1):43.
Published 2017 Jul 21.
doi:10.
1186/s12889-017-4587-y.
[2].
Beware of drugs that induce or aggravate the symptoms of Alzheimer’s[N].
China Medical News,2012-11-07(007).
[3]Wang Sudan.
Drugs that can induce or aggravate Alzheimer’s disease[J].
Health for Everyone,1999 ,09:20.
[4].
Beware of drug-induced senile dementia[J].
Chinese People's Liberation Army Health,2012,04:34.
