There are sensitive structures that cause headaches in the epidural, the soft meninges and the cerebral cerebellum.

Denis Fontaine, a neurosurgery surgeon at the University of the Cote d'Azur in Nice, France, and others looked forward to the observation that mechanical stimulation of intracranial structures in sobriety-opening surgery caused corresponding facial painThe article was published in the April 2018 issue of Brain magazine- From the article(Ref:Fontaine D,et al.
Brain.
 2018 Apr 1;141 (4):1040-1048doi: 10.1093/brain/awy005detection of the sensitive structure of headache is essential for identifying the pathophysiology of primary and secondary headachespreviously believed that small blood vessels and soft meninges in the human brain are insensitive to pain, and that the pain-sensitive structure of the cranial brain is limited to the epidural and its blood-donor blood vessels, large sinuses and the near end of the Willis artery ringneurosurgeon observed acute headaches during microsurgery during sober cranial surgeryobservations show that the distant blood vessels and the soft meninges of the brain may be sensitive to mechanical stimuli and induce headache, involving the pathophysiological process of headachedenis Fontaine, a neurosurgery surgeon at the University of the Cote d'Azur in Nice, France, and others looked forward to the observationthat of the corresponding facial pain caused by mechanical stimulation of intracranial structure sparing intracranial structures during lucid cranial surgeryarticle was published in the April 2018 issue of Brain magazinethe study involved three different neurosurgeons from two medical institutions who removed brain tumors in or near the intracranial "eloquent area" from january 2010 to January 2017 in a sober state, confirming the presence of cortical and subcortical functional brain imaging through direct electrical stimulation In 53 patients, 93 headaches occurred during on-screen tumor removal Each patient experienced 1-5 headaches, an average of 1.8 Tumor pathology was diagnosed with 47 cases of glioma (of which, class II 31 cases, CLASS III 8 cases and IV class 8 cases), 3 cases of neuroscopic glioma, 2 cases of metastatic tumor, 1 case of embryonic dysplasia neuromesothelioma headaches are associated with irritating areas, most of which occur in areas dominated by The Trigons V1 and v3, as well as in areas dominated by V2 and C2 (Figure 1) In 30 patients, 23 stimulus stoic epidurals or 7 exposure to brain sympathisers caused headaches (Figure 2) In these cases, headaches occur mainly in the area dominated by V1 and the tin region In 61 patients, headache was caused by mechanical stimulation of the soft meninges, of which 19 stimulus was caused by the temporal lobe (Figure 3), 25 frontal lobes, 4 top lobes (Figure 4) and the outer side of the brain, including 13 stimulation of the island leaf (Figure 5) It is not possible to distinguish between headache responses that stimulate the soft meninges or cerebrovascular structures and their correlation with stimulation patterns However, it can be determined that the headache is caused by contact or stretching the structure inside the trench or the outer fissure Headaches caused by mechanical stimulation of the soft meninges occur mainly in the area dominated by V1 Figure 1 When mechanicalstimulation of intracranial structures is made, the corresponding pain areas on the face and face A Gray points are the corresponding pain points and white points when stimulating the epidural of the cranial base of the cranial epidural; B The corresponding pain point when stimulating the soft meninges and small blood vessels in the frontal lobe and the front algebra; and C Stimulating the soft meninges and small blood vessels in the temporal lobe grooves Corresponding pain points; D Stimulation of the outer fissure and the soft meninges and small blood vessels in the island-shaped groove, as well as the outer side areas of the brain, including the corresponding pain points in the temporal and frontal lobes; E The facial areas dominated by the trigeminal nerve eye, upper jaw and jaw branches Figure 2 Stimulate headache events in the epidural Left: The cranial epidural and the brain's septum; the numbers indicate the sensitive structural parts of the pain-inducing pain caused by mechanical stimulation Right: The corresponding face pain area number The circled number corresponds to the stimulating part of the brain Number 14 is located on the epidural of the forehead (not shown) figure 3 The side of the brain on the left shows the pain-sensitive structure of the temporal lobe and its number, corresponding to the pain area of the face figure 4 The side of the brain on the left shows the pain-sensitive structural parts of the frontal and top lobes and their numbers, corresponding to the pain area of the face The numbers 53 and 54 are located on the frontal lobe , the outside side of the left brain, showing the painful sensitive structural areas of the outer part of the brain and the edge of the brain, and their number, corresponding to the pain area of the face the study confirmed that the cranial epidural and the brain's sickle meninges are sensitive to pain, and that headaches caused by mechanical stimulation are mainly distributed in the trigeminal V1 and V3 areas Unlike previous findings, the soft meninges and cerebellum are also sensitive to pain, and headaches caused by mechanical stimulation occur mainly in the Trigemite V1 dominant area;