There are new discoveries about metformin.

PHARK, Sept. 23 (Xinhua) -- An analysis of data from more than 730,000 people found that taking aspirin, statins and metformin was associated with a significant negative risk of lung cancer, while those taking the drug had a lower risk.
the study was published recently in the journal Chest Oncology, a leading medical journal.
, 66,024 (9.0%) and 37,031 (5.1%) had taken aspirin and statins, respectively, and 46,205 (6.3%) had type 2 diabetes, of which 25,791 (55.8%) had taken metformin.
23,163 people (3.4%) were taking three drugs at the same time.
, it was found that the incidence and mortality of lung cancer showed a significant negative correlation between the use of metformin, and there was a dose response relationship.
risk of lung cancer was reduced by 11% compared to non-diabetic populations.
, the risk of lung cancer was significantly reduced by 56% and the risk of death significantly by 24% among those who had taken metformin for a cumulative period of 547.5 days over a two-year period.
, lung cancer mortality also showed significant dose dependence reductions with the use of aspirin and statins.
the risk of lung cancer death was significantly reduced by 13% and 23%, respectively, in people who had taken aspirin or statins cumulatively over a two-year period of 547.5 days.
of lung cancer and mortality were reduced by 17 per cent in people who took aspirin, statins and metformin at the same time.
, the risk of lung cancer was reduced by 51% and the risk of lung cancer death by 58% in people who took three drugs at the same time for two years.
study suggests that aspirin, metformin and statins are independently associated with reduced lung cancer risk and may have synergies.
new use of old drugs, in the anti-cancer strategy has a very large potential and expectations.
when it comes to metformin and aspirin, I believe everyone is no longer familiar with it.
these two gods, in recent years brought us a lot of surprises, is our life encountered well-deserved god medicine.
July 10, the official website of the Guangdong Pharmaceutical Society published the "Superdride Instructions For Drug Use Catalog (2020 Edition)," which includes metformin and aspirin.
According to the Superdride Instructions List (2020 edition), metformin can be used for diabetes prevention and treatment of polycystic ovary syndrome, and aspirin can be used to prevent pre-eclampsia.
fact, in recent years, as research has progressed, both metformin and aspirin have made many surprising discoveries that can be used in a wider range of areas.
metformin, which dates back to the 1920s, was extracted from a plant called "goat bean" and was officially used in clinical practice in 1957.
, with aspirin carried the "God medicine" banner.
recently, metformin was once again on the hot search because of the third batch of national harvests.
In the third batch of national collection, the lowest winning bid price of metformin is 1.5 cents per piece, so the price of the people again focused on its wide range of therapeutic effects, especially the much-anticipated anti-cancer effect.
the anti-cancer effect of metformin is not simply reflected in the inhibition of a certain cancer cell, is mainly by activating a phosphate adenosine activated protein kinase (AMPK) and inhibit protein synthesis to play an anti-cancer effect, and the effects of these two effects are systemic, therefore, metformin Bisformin has also been found to have a good effect on cancer in more areas: esophageal squamous cancer: In July, a study published in the Journal of the American Cancer Society found that long-term use of metformin can effectively improve the patient's immune system's ability to fight tumors and inhibit the growth of tumor cells, thereby curbing the development of esophageal squamous cancer.
Gastric Cancer: A clinical trial of metformin published on Cell Stem Cell's official website has shown that metformin can reduce the proliferation of gastric endocular cells, increase the number of stomach wall cells, and have the effect of reducing the risk of stomach cancer.
Bowel Cancer: A study by Chinese researchers published in the well-known journal PNAS showed that in patients with advanced bowel cancer with KRAS mutation, the total survival time of bowel cancer patients who took metformin was 37.8 months longer than in patients with other types of sugar-lowering drugs.
Pancreatic Cancer: The results of an experiment published in the Journal of oncology by the National Cancer Institute of Mexico confirm that metformin can extend the survival of patients with advanced lung adenocarcinoma with EGFR mutations by 14 months.
Ovarian Cancer: Metformin not only reduces the likely development of primary cancer in the ovaries, but also reduces the risk of cancer transferring to the ovaries in other parts of the body, according to a study published in Clinical Cancer Research.
breast cancer: A study of breast cancer in Nature, a leading academic journal, suggests that a combined treatment of metformin and hemolyrobin can inhibit tumor growth.
there is also evidence that the treatment may have the same effect on a variety of cancers, including lung, kidney, uterine, prostate and leukemia.
In addition to fighting cancer, numerous studies have found that metformin has many new effects: anti-aging, weight loss, treatment of hair loss, protection of cardiovascular disease, improvement of gut bacteria, treatment of partial autism, reversal of pulmonary fibrosis, assistance in quitting smoking, reversal of cognitive impairment and so on.
aspirin, also known as acetyl saliolic acid, is a long-established analgesic and was born on March 6, 1899.
it evolved from the bark of the poplar tree, famous, but low-key into the dust.
as early as 1763, scientists first discovered saliolic acid, an active ingredient in aspirin, from the willow bark.
1899, Bayer had sold aspirin worldwide.
can be said that aspirin is the ancestor of the god medicine world.
John A. Baron once said, "If I were on a desert island and could only carry one drug, I would bring aspirin."
aspirin is not only used to treat colds, fevers, headaches, toothaches, joint pain, rheumatology, but also has an inhibitory effect on plateboard aggregation.
, however, the role of aspirin goes far beyond that.
Anti-Alzheimer's Disease: Aspirin promotes its dissolving effect on beta-amyloid protein (A beta), reducing the load on plaques in the brain and, in turn, preventing Alzheimer's disease to some extent, according to an article published in Journal of Neuroscience, a leading American journal of neuroscience.
Diabetes Treatment: Studies have shown that aspirin promotes endogenetic insulin secretion and liver glycogen synthesis, inhibits intestinal absorption of sugar, and promotes tissue sugar intake, thereby reducing blood sugar.
cancer: Gastroenterologists have publicly stated that constantly taking small doses of aspirin can repeatedly reduce the risk of cancer in the liver, stomach and most organs associated with digestion and metabolism.
can multiply the efficiency of immunotherapy, fight leukemia, rectal cancer and other tumors independently, and increase the chances of survival after chemotherapy by 15-20%.
Repair of tooth decay: Studies have found that low doses of aspirin may significantly increase the mineralization of teeth and enhance the expression of genes that form the essence of teeth, and that aspirin's anti-inflammatory and pain-relieving effects may help relieve nerve pain and inflammation caused by individual tooth decay, while also promoting natural dental repair.
aspirin has also been found to cause more malformed sperm in semen for male contraception, and when using amino glycoside antibiotics, the use of aspirin can reduce the occurrence of hearing damage ... It's not over yet, aspirin can be used not only to cure diseases, but also to have many uses in life: when planting or transplanting plants, soaking branches or roots with aspirin solution can improve survival.
Adding the right amount of aspirin to the water of the vase allows the flowers to bloom more lastingly, spraying low concentrations of aspirin solution on the fruit when the fruit is stored, inhibits the formation of ethylene in the fruit and prolongs the storage period of the fruit, and enhances the drought, cold and salt resistance properties of the plants. Although metformin and aspirin have been proven through many scientific studies to have their magical effects in different fields, most of them have only been confirmed in animals and further human trials have yet to be carried out.
, we must not use drugs privately, it is necessary to use drugs under the guidance of professional doctors.
let's hope that there will be more new discoveries and more possibilities in the future of metformin and aspirin.
.