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| There are new clues to "starve" cancer cells through diet |
Science and Technology Daily, Beijing, October 24th (Reporter Zhang Mengran) According to a cancer study recently published in the British journal Nature, a team of American scientists described the latest clue to "starve" cancer cells by restricting calories-diet patterns inhibit the pancreas The unique mechanism of tumor growth in a mouse model of cancer
.
The researchers said that the purpose of this discovery is not to recommend a diet, but to truly understand the underlying biological mechanism.
Low-glycemic index diet interventions such as calorie restriction and ketogenic diets are thought to alter tumor growth-to minimize the peak blood sugar and insulin levels.
This effect is related to the inhibition of tumor growth in some animal models
.
However, whether other metabolic changes associated with this type of diet will affect tumor growth remains to be studied
Matthew Fanda Hayden, a scientist at MIT’s Koch Institute for Comprehensive Cancer Research, collaborated with researchers at the Dana-Farber Cancer Research Center at Harvard Medical School to analyze the effects of calorie restriction and ketogenic diet on pancreatic cancer mice The influence of the model
.
Experiments have found that it is calorie restriction rather than a ketogenic diet that can reduce blood lipid levels in plasma and tumors.
In addition to mouse experiments, the research team also analyzed the relationship between dietary patterns and survival time of 1,165 pancreatic cancer patients
.
Preliminary findings indicate that a diet high in fat and low in carbohydrates may be related to longer survival time for patients
However, the researchers also pointed out that a low-glycemic index diet is not suitable for all cancer patients.
This diet is sometimes difficult to adhere to and tolerate, and weight loss may also limit the choice of treatment options
.
They believe that further research on how diet affects the metabolic changes that interfere with tumor growth, or can guide how to add diets or therapies that mimic such effects to existing cancer treatment strategies, and develop new drugs to inhibit the activity of this enzyme
