The Zhongke Seilifu study found that cd38 high-expressors in vivo did not respond to NMN

Recently, Sci-Li Fu (China) and the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences jointly established Zhongke Sali Complex Mitochondrial Medicine (Shenzhen) Co.

Through the strong alliance, the two sides will give full play to their respective resource advantages, focusing on the development and application of anti-aging molecule NAD+, the screening of anti-aging substances, anti-aging multi-target exploration and other cutting-edge technology research, new product development, technology platform establishment and talent training and other aspects of extensive and in-depth cooperation, to establish a long-term technology development platform and a good platform for the transformation of scientific research achievements

It is reported that Seliv (China) is a high-tech enterprise with AI multi-target anti-aging, with a strong scientific research team and R & D application platform, which can continuously transform cutting-edge core technologies into health products

NAD+ is an indispensable coenzyme component in hundreds of enzyme proteins in the human body, dominating hundreds of life activities in the human body, which is essential for regulating cellular aging and maintaining normal functions of the body, but direct supplementation of NAD+ is difficult to be absorbed by the human body, and the efficiency is extremely low, researchers turned to "curve to save the country" to study the precursor substances and other forms of

Yu Liyang, the first person to invent the NAD+ high-throughput protein probe detection technology and a doctoral supervisor of the Computer-Aided Drug Design and Research Center of the Shenzhen Advanced Institute of the Chinese Academy of Sciences, expressed his views on NMN: "First of all, we must admit that NMN is effective, but we must also admit that some people do not respond to

Yu Bo mentioned that a clinical trial in the United States in 2021 confirmed that the blood NAD+ level of the subject after oral NMN was greatly heterogeneous (1), and in 2022, there were also clinical trial papers in Japan showing that there were people with weak response after oral NMN (2), and the latest human clinical trial data of Guangzhou Sport University for NMN supplementation in China's key research and development program in which Sai Lifu participated also showed that there were indeed some people who did not respond

Through the in-depth study of this phenomenon, it was found that aging-induced inflammation promotes the high expression of CD38 in immune cells, and CD38 reduces the body's absorption level

Yu Bo introduced that hydrogenated molecules such as NADH, NRH and NMNH that enter cells through different pathways from NMN are speculated not to be affected by CD38, which is a potentially more efficient way to

At present, Selivor has overcome the problem that NADH is difficult to maintain for a long time, produced a force living element (NADH) that can still ensure stability under storage conditions of up to 3 years, and obtained a number of invention patent certificates

It is understood that Zhongke Sai Lifu also plans to carry out "super clinical trials" with "NAD+ detection" as a technological breakthrough, and apply the world's first NAD+ probe high-throughput detection technology to a deeper level of research

The traditional NAD+ detection method requires the use of mass spectrometers and chromatographs with a large volume and a single price of more than 700,000 yuan, with a professional testing team, to get the results

Prior to this, aging has no way to measure, so it is difficult to effectively intervene and manage it, Zhongke Seligfu based on NAD+ probe technology to achieve NAD + high-throughput detection program, can better assess the degree of aging, while through NAD+ detection can also find NMN does not respond to the population, to provide them with customized solutions

In the future, Zhongke Sai Lifu will measure aging, through a comprehensive evaluation of a person's aging degree, to help human beings achieve more accurate intervention in aging, improve the current situation of population aging from the social level, and improve the quality of life of

It is believed that with more and more powerful combinations, science and technology will show explosive development, and aging will become a disease

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