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The use of CRISPR screening technology may be expected to identify new drug targets for the treatment of AML

 Last Update: 2021-10-02
 Source: Internet
 Author: User

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The transformation state of acute leukemia requires certain gene regulation procedures, and these procedures mainly involve transcription factors and chromatin regulators

Researcher Junwei Shi said that now we have found that cancer cells in AML patients are heavily dependent on ZMYND8, and thanks to this complex CRISPR-based screening method, we can determine specific targets that can be used as medicines

AML affects the health of more than 20,000 patients each year, including children and adults, and the 5-year survival rate for patients over 20 years old is only 27%.

The use of CRISPR screening technology may be expected to identify new drug targets for the treatment of acute myeloid leukemia

Image source: Zhendong Cao, et al.

In the article, the researchers used CRISPR technology to precisely destroy the domain function of the protein in cancer cells.

Note: The original text has been deleted

Original source:

Zhendong Cao, Krista A.

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