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3-(Bromomethyl)pyridazine is an organic compound with the chemical formula C6H8N2Br.
It is a white or slightly yellowish crystalline solid with a distinctive odor.
It is soluble in water and many organic solvents.
3-(Bromomethyl)pyridazine is commonly used in the chemical industry as an intermediate for the production of other chemicals and drugs.
In this article, we will discuss the upstream and downstream products of 3-(bromomethyl)pyridazine in the chemical industry.
Upstream Products
The upstream products of 3-(Bromomethyl)pyridazine are the raw materials required for its production.
The main upstream products include:
- Pyrimidine: Pyrimidine is an organic compound with the chemical formula C4H6N2.
It is a white crystalline solid that is used as a starting material for the production of 3-(Bromomethyl)pyridazine. - Propionaldehyde: Propionaldehyde is an organic compound with the chemical formula CH3CH2CHO.
It is a colorless gas that is used as a starting material for the production of 3-(Bromomethyl)pyridazine. - N-Bromosuccinimide: N-Bromosuccinimide is an organic compound with the chemical formula C7H11BrN2OS.
It is a white or slightly yellowish solid that is used as a starting material for the production of 3-(Bromomethyl)pyridazine.
Downstream Products
The downstream products of 3-(Bromomethyl)pyridazine are the chemicals and drugs that are produced using 3-(Bromomethyl)pyridazine as an intermediate.
The main downstream products include:
- Anti-TB drugs: 3-(Bromomethyl)pyridazine is used as an intermediate for the production of anti-TB drugs, such as Ethionamide and Prothionamide.
These drugs are used to treat tuberculosis. - Pigments: 3-(Bromomethyl)pyridazine is used as an intermediate for the production of pigments, such as phthalocyanine blue and green.
- Corrosion inhibitors: 3-(Bromomethyl)pyridazine is used as an intermediate for the production of corrosion inhibitors, which are used to protect metal surfaces from corrosion.
Production Process
The production process of 3-(Bromomethyl)pyridazine involves several steps, including:
- Synthesis of Pyrimidine: Pyrimidine is synthesized using commercial phosphorus trichloride and hydroiodic acid.
- Synthesis of Propionaldehyde: Propionaldehyde is synthesized by the reduction of propionic acid using zinc dust and hydrogen gas.
- N-Bromosuccinimide synthesis: N-Bromosuccinimide is synthesized by the bromination of succinic acid using nitrogen bromide.
- Synthesis of 3-(Bromomethyl)pyridazine: 3-(Bromomethyl)pyridazine is synthesized by the reaction of N-Bromosuccinimide with pyrimidine and propionaldehyde.
- Purification and isolation: The final product is purified and isolated by crystallization, filtration, and recrystallization.
Raw Materials
The raw materials required for the production of 3-(Bromomethyl)pyridazine are pyrimidine, propionaldehyde, and N-Bromosuccinimide.
Pyrimidine and propionaldehyde are