The United States has developed a new drug for acute myeloid leukemia
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Last Update: 2020-12-17
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Source: Internet
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Author: User
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protein drug that promises to be used to treat acute myeloid leukemia is now in clinical trials in the United States, according to a study published wednesday in the United States.
previous studies have shown that overexpression of the MDMX and MDM2 genes inhibits the activity of the cancer-fighting gene p53, which can lead to certain cancers. But the anti-cancer drugs previously studied by the medical community were limited to MDM2 inhibitors.
at the Einstein College of Medicine in the United States have developed a new drug that inhibits both MDMX and MDM2, fully activating p53 to make it cancer-fighting. This new drug belongs to the subscription peptide. The spiral structure of the stapled peptide is more stable and prevents the drug from being degraded by enzymes before reaching the target.
experiments have shown that the new drug extends the mid-life of mice transplanted with human leukemia cells from 50 to 150 days. About 40% of mice were even cured by the drug and had not developed the disease for more than a year.
drug is expected not only to treat acute myeloid leukemia, but also to treat other p53-related cancers, researchers said. (Source: Xinhua News Agency Zhou Zhou)
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