The three cells most vulnerable to new coronavirus are found

An international team of researchers said in the journal Cell that they found three cell types most likely to be attacked by the new coronavirus in the human lungs, nasal cavity and intestines, and found that the coronavirus may use the natural defenses of host cells to hijack some proteins for their own use. Sharing the data and findings as soon as possible will help focus efforts on how the new coronavirus attacks the human body, better test existing antiviral therapies, and help scientists develop new treatments for the new coronary pneumonia, they said.Researchers say the new coronavirus invades cells with two key "helpers": angiotensin-converting enzyme 2 (ACE2) and TMPRSS2 protease. ACE2 is the subject of a virus entering the host cell, and the new coronavirus's hedgehog protein invades the body by hijacking ACE2; But which cells express these two types of proteins remains a mystery.Scientists from the Massachusetts Institute of Technology and Harvard University, together with colleagues from around the world, used existing RNA-related data found in different types of cells to search for cells that express these two specific proteins, and found that cup-like secretion cells that secrete snot in the nasal cavity, type II.type vesicle cells in the veins responsible for maintaining the function of the veles, and absorbent intestinal cortical cells in the gut responsible for nutrient absorption are more able to express RNA of both proteins than other cells.

addition, the researchers found a surprising phenomenon: the expression of the ACE2 gene appears to be related to the activation of genes known to be turned on by interferon. Interferon is a protein produced by the body infected with the virus, by interfering with the virus replication and activation of immune cells to fight infection, this is the first time scientists have found that ACE2 is associated with interferon reaction, indicating that the coronavirus may use the host cell's natural defenses to hijack some proteins for their own use. It also suggests that interferon's role in fighting neocyto pneumonia can be complex: on the one hand, it stimulates genes to fight infection or help cells fight damage, but on the other hand, it can provide additional targets to help the virus infect more cells. (Science and Technology daily
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