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Neonicotinoids insecticides (NEOs) are an emerging pesticide developed on the basis of nicotine structure, with high efficiency, broad spectrum and good photostability
The fetal period and early postnatal life are critical periods of human growth and development and are susceptible to adverse effects from environmental exposures
The research group of Tian Ying and Gao Yu from the School of Public Health of Shanghai Jiao Tong University will publish the title "Prenatal Neonicotinoid Inseccicides Exposure, Oxidative Stress, and Birth Outcomes" online in the well-known journal "Environment International" in the field of environmental science in March 2022.
This study is based on the Laizhou Wan Birth Cohort (LWBC) established in the Laizhou Bay area of Shandong Province.
Among the five NEOs and metabolites tested, 6-CN had the highest exposure, with a median creatinine-corrected concentration of 9.
Table 1 The relationship between NEOs and 8-OHdG levels in the third trimester of pregnant women and birth outcomes
Figure 1 The relationship between NEOs exposure in the third trimester of pregnant women and birth outcomes (sex stratification)
Further mediation effect analysis (Figure 2) found that 8-OHdG mediated the negative correlation between IMI, 2CTCA, ND-ACE and birth head circumference, and the mediation proportions were 38.
Figure 2 Mediating analysis of 8-OHdG between NEOs exposure during pregnancy and birth head circumference
Figure 3 Mediating analysis of 8-OHdG in NEOs exposure during pregnancy and birth head circumference in girls
Although more and more scholars have begun to pay attention to the exposure levels of NEOs in different populations, studies on NEOs exposure assessment in pregnant women are still very limited
Pan Chengyu, a 2019 graduate student of Shanghai Jiao Tong University School of Medicine, and Yu Jinxia from the University of Science and Technology of China are the co-first authors of the paper, and Professor Gao Yu and Professor Tian Ying from the School of Public Health of Shanghai Jiao Tong University are the co-corresponding authors of the paper
