The team of Professor Xu Zhenghong from the School of Bioengineering of Jiangnan University has made important progress in the anti-inflammatory mechanism of grain vinegar ointment and the regulation of intestinal microbes.

Recently, the team of Professor Xu Zhenghong from the School of Bioengineering of Jiangnan University has made important progress in the research on the anti-inflammatory mechanism of cereal vinegar ointment.
The research result "Cereal Vinegar Sediment Alleviates Spontaneous Ulcerative Colitis in Il-10 Deficient Mice" was officially published in "Molecular Nutrition & Food Research" (https://doi.
org/10.
1002/mnfr.
202001227)
.

Professor Xu Zhenghong is the corresponding author, and Professor Geng Yan from the School of Pharmacy of Jiangnan University is the first author and co-corresponding author

Traditional vinegar has a history of more than a thousand years in China.
It is made from grains such as sorghum, rice, glutinous rice, etc.
, and fermented by a variety of microorganisms.
It uses traditional fermentation and brewing technology and passes through multiple production processes to produce a unique flavor and rich content.
Functional food with ingredients
.

Cereal vinegar paste (CVS) is a sediment produced during the preservation of traditional vinegar brewed from grains, which is rich in proteins, organic acids, polysaccharides, polyphenols and flavonoids

This study has unearthed the health functions and mechanisms of traditional grain vinegar cream, showing that it can reduce inflammation markers and change the intestinal flora through dietary intervention, and may be a powerful regulator of the body's microbiome and immune system
.

Further use modern biological science and technology to improve the quality and functions of traditional vinegar, and develop functional vinegar products such as new traditional vinegar concentrates to contribute to a healthy China

Project funding

The above-mentioned research work was funded by the National Natural Science Foundation of China (31970746) and the "Blue Project" of Jiangsu Province
.

Corresponding author profile

Xu Zhenghong is a professor, doctoral supervisor and dean of the School of Bioengineering, Jiangnan University
.

He has long been engaged in research in the fields of microbial ecology of traditional brewed foods, biomanufacturing and functional evaluation of nutritional chemicals, and is mainly responsible for teaching courses such as "Microbial Ecology"

2002.

[1] Director of Jiangsu Pharmacological Society[2] Member of Chinese Society of Cell Biology[3]Member of Chinese Biophysical Society

The main research topics in the past 5 years:

[1] Discovery of new targets for the treatment of organ fibrosis and research on its molecular mechanism of action
.

[2] Screening of anti-fibrotic bioactive substances and research on molecular pharmacological mechanism

[1] National Natural Science Foundation of China, 31970746, Study on the mechanism of desulfovibrio inducing liver fibrosis through the gut-hepatic axis, 2020.
01-2023.
12
.
[2] National Natural Science Foundation Project, 31771514, The role of Fstl1 in the fate determination of hepatic stellate cells during the progression and regression of liver fibrosis, 2018.
01-2021.
12
.
[3] 2020 Jiangsu University "Blue Project" training target outstanding young backbone teachers, 2020.
05-2023.
05
.