The team of Dong Ruijiao of Shanghai Jiaotong University and collaborators jointly developed a new strategy for the preparation of orderly porous nanofilms that can be used for accurate screening of drugs

Recently, the latest issue of Nature magazine reported the collaborative research results of The Dong Ruijiao team of the Institute of Systems Biomedicine at Shanghai Jiao Tong University, Queen Mary University/Imperial College of London Jiang Zhiwei and Andrew Livingston' team Ataligned macrocycle pores in ultrathin films for accurate molecular sieving.

In industrial applications such as chemical, petroleum, pharmaceutical, etc.

To solve this problem, the researchers used macrocyclic molecules (cyclodextrins, CD) as the building block, selectively modified the hydroxyl groups at one end of the CD to highly active amino groups, and long links them to the macrocyclic molecules through flexible polyurethanes, while the functional groups at the other end remain unchanged

Figure 1.

A two-step method is taken to prepare a composite nanofilm, which is first polymerized at a free interface to form a self-supporting polyamide membrane separation layer (Figures 2a, b), and then transferred to the substrate to form a composite film (Figure 2c).

In order to study the arrangement structure of large CD rings in nanofilms, self-supporting ultra-thin films were first analyzed

Figure 2.

Orderly aligned membrane pores can effectively reduce the mass transfer resistance of molecules in membrane pores, thereby achieving accurate screening between molecules of similar size

Figure 3.

To further elucidate the importance of such ordered porous nanofilms in the separation of high value-added drugs, the researchers chose cannabidiol (CBD) as a demonstration case

Figure 4.

summary

Precisely adjustable pore size membrane materials are necessary to

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