-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Written | nagashi editor | Wang Duoyu typesetting | Shuichengwen As the northern hemisphere enters winter, and the new crown mutant strain Omicron (Omicron), a new wave of new crown epidemic seems to be emerging
.
Recently, small-scale new crown epidemics have appeared in Xi'an, Shaanxi and other places.
The number of confirmed cases per day is still increasing, and the turning point of the epidemic has not yet arrived
.
Fighting the new crown epidemic is a protracted battle, and vaccination is a powerful means to prevent new crown infection
.
The latest data show that China's current vaccination rate has reached more than 80%
.
Unfortunately, the protective effect of vaccination will be weakened at about 6 months, especially in the elderly
.
However, it is obviously a huge challenge to carry out vaccination every 6 months or every year to improve protection, and it is not the best public health strategy
.
Recently, Academician Xu Jianguo of the Chinese Center for Disease Control and Prevention and the team of Professor Xu Jianqing of the Institute of Biomedical Research of Fudan University carried out a collaborative study and published an online publication in the Frontiers in Nutrition journal titled: Boosting vaccine-elicitedrespiratory mucosal and systemic COVID-19 immunity in mice with the oral Lactobacillus Plantarum's research paper
.
This study shows that oral administration of Lactobacillus plantarum Guanke strain (GUANKE) can enhance the specific immunity against the new coronavirus produced by laboratory mice vaccinated with the new crown vaccine, including neutralizing antibody levels and T cell response indicators
.
Six months after mice were vaccinated, oral administration of Lactobacillus plantarum Guanke strain (GUANKE) can promote and maintain the production of neutralizing antibodies against the new coronavirus
.
Academician Xu Jianguo said that if we can obtain results similar to mouse experiments in the study of vaccinated populations, we may provide a new weapon for the prevention and control of the new crown
.
We all know that there are many symbiotic flora in the human body, and even in a sense, "human" is a multiple complex of humans and symbiotic flora
.
These symbiotic flora affect all aspects of our lives to a certain extent, including health, physical fitness, character and even life span
.
Therefore, proper intake of probiotics is beneficial to our health
.
Previous studies have shown that the unique probiotics-Lactobacillus plantarum strain (GUANKE) can enhance the interferon signaling pathway, inhibit apoptosis and inflammation pathways, and promote the effective period and memory period of the SARS-CoV-2 specific immune response
.
Based on this, the research team hypothesized that oral administration of the strain can enhance and prolong the immune response triggered by the new crown vaccine by regulating the mechanism of innate and acquired immune response
.
Experimental flowchart The research team first vaccinated the mice with the new crown vaccine, and immediately administered the GUANKE strain of Lactobacillus plantarum (GUANKE), and then monitored the mice's antibody levels and T cell responses
.
They found that compared with the control group mice that were only vaccinated with the new crown vaccine, the neutralizing antibody titer in the serum of the experimental group of mice increased by two times, and the neutralizing antibody titer in the bronchoalveolar lavage fluid (BAL) increased.
8 times
.
Six months after being vaccinated with the new crown vaccine, oral administration of the crown gram strain can improve the humoral immune response of mice.
Not only that, the experimental group mice also showed enhanced T cell response-T in bronchoalveolar lavage fluid (BAL) and spleen Cell response is maintained longer than the control group
.
Related to this, in another influenza vaccine clinical trial, the use of probiotics increased the ratio of natural killer cells, T helper cells, and T cytotoxic cells
.
Immediately after immunization, oral administration of Coronavirus strain can improve the body fluid and cellular immune response of mice.
The research team further conducted transcriptome analysis on the spleen cells, mediastinum, mesenteric lymph nodes and intestinal tissues of mice in the experimental group of oral administration of Coronavirus strain
.
They found that the intake of this strain can significantly promote the body's interferon response, inhibit apoptosis and inflammatory response, and promote the activation, proliferation, differentiation and memory of B and T cells
.
This also explains why this strain can promote the host immune response
.
Oral corona strain can down-regulate inflammation and apoptosis in mouse lymphatic tissues and promote interferon signaling pathway.
In summary, this study shows that a probiotic, Lactobacillus plantarum corona strain (GUANKE) can be used as an adjuvant with The combined application of the new crown vaccine enhances and prolongs the immune protection caused by the new crown vaccine, and improves the effectiveness of the vaccine
.
In addition, because the main pathogenic mechanism of the new crown is to promote inflammation, the crown strain has a significant inhibitory effect on inflammation
.
Therefore, oral administration of the strain may reduce inflammation in the respiratory tract and help inhibit the replication of the new coronavirus, thereby improving clinical performance and promoting patient recovery
.
Regarding the Lactobacillus plantarum Kwanke strain Lactobacillus plantarum Kwanker strain was isolated from healthy human feces specimens and belongs to the “list of strains that can be used in food” promulgated by the National Health Commission
.
The strain does not carry any antibiotic resistance genes or virulence genes, and large amounts of consumption will not cause any tissue pathological damage and heterotopic colonization to the host
.
This strain can be applied to the product development of edible fungi, and is expected to be applied to the vaccinated population, which can significantly improve the protective effect of the new crown vaccine
.
About Frontiers in Nutrition Frontiers in Nutrition is an open access journal under the Swiss publishing house Frontiers Press.
It has a new impact factor of 6.
576 and is located in JCR Division 1.
The editor-in-chief is Professor Johannes le Coutre from the University of New South Wales
.
The goal of the journal is to establish a platform based on original research, clinical experiments and reviews, and establish a reputable knowledge forum in the fields of human health, dietary behavior, agronomy and food science
.
The journal mainly focuses on the following 13 research directions: Frontiers, headquartered in Switzerland, is the world's leading Open Access publisher, committed to making science more open on a global scale
.
For more details, welcome to visit Frontiers official website: Paper link: https:// is open for reprinting, welcome to forward to Moments and WeChat groups
.
Recently, small-scale new crown epidemics have appeared in Xi'an, Shaanxi and other places.
The number of confirmed cases per day is still increasing, and the turning point of the epidemic has not yet arrived
.
Fighting the new crown epidemic is a protracted battle, and vaccination is a powerful means to prevent new crown infection
.
The latest data show that China's current vaccination rate has reached more than 80%
.
Unfortunately, the protective effect of vaccination will be weakened at about 6 months, especially in the elderly
.
However, it is obviously a huge challenge to carry out vaccination every 6 months or every year to improve protection, and it is not the best public health strategy
.
Recently, Academician Xu Jianguo of the Chinese Center for Disease Control and Prevention and the team of Professor Xu Jianqing of the Institute of Biomedical Research of Fudan University carried out a collaborative study and published an online publication in the Frontiers in Nutrition journal titled: Boosting vaccine-elicitedrespiratory mucosal and systemic COVID-19 immunity in mice with the oral Lactobacillus Plantarum's research paper
.
This study shows that oral administration of Lactobacillus plantarum Guanke strain (GUANKE) can enhance the specific immunity against the new coronavirus produced by laboratory mice vaccinated with the new crown vaccine, including neutralizing antibody levels and T cell response indicators
.
Six months after mice were vaccinated, oral administration of Lactobacillus plantarum Guanke strain (GUANKE) can promote and maintain the production of neutralizing antibodies against the new coronavirus
.
Academician Xu Jianguo said that if we can obtain results similar to mouse experiments in the study of vaccinated populations, we may provide a new weapon for the prevention and control of the new crown
.
We all know that there are many symbiotic flora in the human body, and even in a sense, "human" is a multiple complex of humans and symbiotic flora
.
These symbiotic flora affect all aspects of our lives to a certain extent, including health, physical fitness, character and even life span
.
Therefore, proper intake of probiotics is beneficial to our health
.
Previous studies have shown that the unique probiotics-Lactobacillus plantarum strain (GUANKE) can enhance the interferon signaling pathway, inhibit apoptosis and inflammation pathways, and promote the effective period and memory period of the SARS-CoV-2 specific immune response
.
Based on this, the research team hypothesized that oral administration of the strain can enhance and prolong the immune response triggered by the new crown vaccine by regulating the mechanism of innate and acquired immune response
.
Experimental flowchart The research team first vaccinated the mice with the new crown vaccine, and immediately administered the GUANKE strain of Lactobacillus plantarum (GUANKE), and then monitored the mice's antibody levels and T cell responses
.
They found that compared with the control group mice that were only vaccinated with the new crown vaccine, the neutralizing antibody titer in the serum of the experimental group of mice increased by two times, and the neutralizing antibody titer in the bronchoalveolar lavage fluid (BAL) increased.
8 times
.
Six months after being vaccinated with the new crown vaccine, oral administration of the crown gram strain can improve the humoral immune response of mice.
Not only that, the experimental group mice also showed enhanced T cell response-T in bronchoalveolar lavage fluid (BAL) and spleen Cell response is maintained longer than the control group
.
Related to this, in another influenza vaccine clinical trial, the use of probiotics increased the ratio of natural killer cells, T helper cells, and T cytotoxic cells
.
Immediately after immunization, oral administration of Coronavirus strain can improve the body fluid and cellular immune response of mice.
The research team further conducted transcriptome analysis on the spleen cells, mediastinum, mesenteric lymph nodes and intestinal tissues of mice in the experimental group of oral administration of Coronavirus strain
.
They found that the intake of this strain can significantly promote the body's interferon response, inhibit apoptosis and inflammatory response, and promote the activation, proliferation, differentiation and memory of B and T cells
.
This also explains why this strain can promote the host immune response
.
Oral corona strain can down-regulate inflammation and apoptosis in mouse lymphatic tissues and promote interferon signaling pathway.
In summary, this study shows that a probiotic, Lactobacillus plantarum corona strain (GUANKE) can be used as an adjuvant with The combined application of the new crown vaccine enhances and prolongs the immune protection caused by the new crown vaccine, and improves the effectiveness of the vaccine
.
In addition, because the main pathogenic mechanism of the new crown is to promote inflammation, the crown strain has a significant inhibitory effect on inflammation
.
Therefore, oral administration of the strain may reduce inflammation in the respiratory tract and help inhibit the replication of the new coronavirus, thereby improving clinical performance and promoting patient recovery
.
Regarding the Lactobacillus plantarum Kwanke strain Lactobacillus plantarum Kwanker strain was isolated from healthy human feces specimens and belongs to the “list of strains that can be used in food” promulgated by the National Health Commission
.
The strain does not carry any antibiotic resistance genes or virulence genes, and large amounts of consumption will not cause any tissue pathological damage and heterotopic colonization to the host
.
This strain can be applied to the product development of edible fungi, and is expected to be applied to the vaccinated population, which can significantly improve the protective effect of the new crown vaccine
.
About Frontiers in Nutrition Frontiers in Nutrition is an open access journal under the Swiss publishing house Frontiers Press.
It has a new impact factor of 6.
576 and is located in JCR Division 1.
The editor-in-chief is Professor Johannes le Coutre from the University of New South Wales
.
The goal of the journal is to establish a platform based on original research, clinical experiments and reviews, and establish a reputable knowledge forum in the fields of human health, dietary behavior, agronomy and food science
.
The journal mainly focuses on the following 13 research directions: Frontiers, headquartered in Switzerland, is the world's leading Open Access publisher, committed to making science more open on a global scale
.
For more details, welcome to visit Frontiers official website: Paper link: https:// is open for reprinting, welcome to forward to Moments and WeChat groups
