The team found the brain's sleep quality control mechanisms

sleep problem has become a global problem. Recently, Liu Chang, a researcher at the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, in collaboration with Leslie C. Griffith, a professor at Brandis University in the United States, used fruit flies as a model organism to discover neural loops in the brain that regulate sleep quality, further analyze the neural mechanisms that regulate sleep, and provide new therapeutic intervention targets and potential therapeutic strategies for coping with sleep problems. The findings were published On October 24th in the journal Cell, Current Biology.
exploring the mystery of sleep quality, the team looked at an important neurotransmitter, pyrethromylamphetamine. To find out the relationship, the team first found special genes for expression in the five serotonin neurons in the fruit fly's brain, and then stimulated them with "light" or "heat", which releases molecular signals. These excited oxycodone neurons cause sleep fragmentation. The team also found that in the brain region of the fruit fly's brain, a doughnut-shaped sphere, a class of specific recipients received these signals, stimulating these recipient neurons, which also led to sleep fragmentation in the fruit fly. "Compared to the control group, fruit flies with special neural loop activations woke up an average of 15 to 20 times during the day and 10 to 15 times during the night." Liu Chang introduced.
it's worth noting that the "doughnut" brain region, where these recipients receive signals and interrupt sleep, has long been thought to regulate movement and perception, similar to the "navigator" in the brain of fruit flies. The relationship between the brain region and sleep stability has only been paid attention to by the academic circles in recent years, and this research reveals for the first time the mechanism of the brain region's regulation of sleep quality.
" Although the neurodefringment mechanism of sleep quality is found in the brains of fruit flies, experiments have confirmed that the relationship between specific subjects and sleep quality found in mammals is also present in behavioral and physiological factors. Liu Chang said the next step will continue to focus on the molecules downstream of the target involved in regulating sleep quality.
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