The Synthetic Routes of Vandetanib

Vandetanib is a medication used to treat certain types of cancer, particularly medullary thyroid cancer and mantle cell lymphoma.
The synthesis of vandetanib involves a number of steps, and there are several different synthetic routes that can be used to produce this compound.
In this article, we will explore some of the most commonly used synthetic routes for vandetanib, including the Stille coupling, the Suzuki-Miyaura coupling, and the Sonogashira coupling.

The Stille coupling is a common method used to synthesize vandetanib.
This method involves the reaction of a phenyllithium with a substituted furan, such as a 4-substituted-2H-chromen-2-one, to form a new carbon-carbon bond.
The reaction typically proceeds through a free radical mechanism, with the formation of a phenyl radical as a reactive intermediate.
The Stille coupling is a versatile method that can be used to synthesize a wide variety of compounds, including vandetanib.

The Suzuki-Miyaura coupling is another popular method used to synthesize vandetanib.
This reaction involves the coupling of a boronic acid with a palladium catalyst in the presence of a base.
The reaction proceeds through a metal-mediated mechanism, with the boronic acid and the palladium catalyst reacting to form a new carbon-carbon bond.
The Suzuki-Miyaura coupling is a reliable method that is commonly used to synthesize a wide variety of compounds, including vandetanib.

The Sonogashira coupling is a common method used to synthesize vandetanib.
This reaction involves the reaction of a phenyllithium with a substituted iodoarene to form a new carbon-carbon bond.
The reaction proceeds through a free radical mechanism, with the formation of a phenyl radical as a reactive intermediate.
The Sonogashira coupling is a versatile method that can be used to synthesize a wide variety of compounds, including vandetanib.

In conclusion, vandetanib can be synthesized using a variety of different methods, including the Stille coupling, the Suzuki-Miyaura coupling, and the Sonogashira coupling.
These reactions are commonly used in the synthesis of a wide variety of compounds, and they are all reliable methods that can be used to synthesize vandetanib.