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Tert-Butyl (3-(benzyloxy)-2-((2-(2,2-dimethoxyethoxy)ethyl)carbamoyl)-4-oxopyridin-1(4H)-yl)carbamate is an organic compound that has increasingly gained attention in the chemical industry due to its diverse range of applications.
This compound can be synthesized through several synthetic routes, each of which has its own advantages and disadvantages.
One of the most common methods of synthesizing Tert-Butyl (3-(benzyloxy)-2-((2-(2,2-dimethoxyethoxy)ethyl)carbamoyl)-4-oxopyridin-1(4H)-yl)carbamate involves a multistep synthesis process that involves several chemical reactions.
The synthesis process typically starts with the preparation of several key intermediates, which are then combined to form the final compound.
One of the first steps in the synthesis of Tert-Butyl (3-(benzyloxy)-2-((2-(2,2-dimethoxyethoxy)ethyl)carbamoyl)-4-oxopyridin-1(4H)-yl)carbamate involves the preparation of a benzyl alcohol derivative.
This is typically done by treating a benzyl Halide or benzyl Grignard reagent with a strong base such as sodium hydroxide or potassium hydroxide.
The resulting benzyl alcohol derivative is then treated with a carboxylic acid derivative to form a benzyl carboxylate.
The next step involves the preparation of a Mannich base derivative, which is typically done by reacting the benzyl carboxylate with formaldehyde and an amine such as para-amino benzonitrile.
The resulting Mannich base derivative is then treated with a second carboxylic acid derivative to form a key intermediate.
The final step in the synthesis of Tert-Butyl (3-(benzyloxy)-2-((2-(2,2-dimethoxyethoxy)ethyl)carbamoyl)-4-oxopyridin-1(4H)-yl)carbamate involves the condensation of the key intermediate with a tert-butyl carbamate derivative.
The resulting compound is then treated with a hydroxylating agent such as sodium hydroxide to form the final compound.
Another synthetic route to Tert-Butyl (3-(benzyloxy)-2-((2-(2,2-dimethoxyethoxy)ethyl)carbamoyl)-4-oxopyridin-1(4H)-yl)carbamate involves using a Suzuki-Miyaura cross-coupling reaction.
This reaction involves the nucleophilic addition of a boronic acid derivative to an aryl halide in the presence of a palladium catalyst.
The resulting boronic acid derivative is then treated with a second boronic acid derivative and a tert-butyl carbamate derivative to form the final compound.
The choice of synthetic route depends on several factors, including the availability of starting materials, the scale of production, and the desired purity of the final product.
The multistep synthesis process typically requires more starting materials and longer reaction times compared to the Suzuki-Miyaura cross-coupling reaction, which can be more efficient and cost-effective for large-scale production.
Tert-Butyl (3-(benzyloxy)-2-((2-(2,2-dimethoxyethoxy)ethyl)carbamoyl)-4-oxopyridin-1(4H)-yl)carbamate is a valuable intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other industrial chemicals.
Its unique structural features and diverse range of applications make it an important compound in the chemical industry.
In conclusion, the synthetic routes to Tert-Butyl (3-(benzyloxy)-2-((2-(2