The Synthetic Routes of (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE

The synthetic route to (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE is a complex and multi-step process that involves several chemical reactions and purifications.
The final product is an important intermediate in the synthesis of antimicrobial and antiviral agents.
This article will provide a detailed overview of the synthetic routes to (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE in the chemical industry.

Step 1: BENZYL 2,6-DIOXOHEPTANOATE

The first step in the synthesis of (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE involves the preparation of BENZYL 2,6-DIOXOHEPTANOATE.
This compound can be synthesized by a two-step reaction using benzylamine and malonic acid in the presence of an acid catalyst.
The first step is the condensation of benzylamine and malonic acid to form N-benzylmalonamide.
The second step is the hydrolysis of N-benzylmalonamide in the presence of an acid catalyst to form BENZYL 2,6-DIOXOHEPTANOATE.

Step 2: 2,6-DIOXOHEPTANOIC ACID

The next step in the synthesis of (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE involves the preparation of 2,6-DIOXOHEPTANOIC ACID.
This compound can be synthesized by a conventional dehydration reaction using BENZYL 2,6-DIOXOHEPTANOATE.
The reaction is typically carried out using a strong acid catalyst, such as phosphoric acid, and results in the formation of 2,6-DIOXOHEPTANOIC ACID.

Step 3: 2,6-DIOXOHEPTANOIC ACID HYDROCHLORIDE

The next step in the synthesis of (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE involves the preparation of 2,6-DIOXOHEPTANOIC ACID HYDROCHLORIDE.
This compound can be synthesized by a conventional hydrolysis reaction using 2,6-DIOXOHEPTANOIC ACID in the presence of hydrochloric acid.
The reaction is typically carried out using a strong acid catalyst, such as hydrochloric acid, and results in the formation of 2,6-DIOXOHEPTANOIC ACID HYDROCHLORIDE.

Step 4: N,N-DIETHYL-2,6-DIOXO-L-ALANINE TETRACHLORODIMETHYL CARBAMATE

The next step in the synthesis of (S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE involves the preparation of N,N-DIETHYL-2,6-DIOXO-L-ALANINE TETRACHLORODIMETHYL CARBAMATE.
This compound can be synthesized by a multi-step reaction using 2,6-DIOXOHEPTANOIC ACID HYD