The Synthetic Routes of Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, monophenyl ester

Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, monophenyl ester, also known as PUR131, is an important intermediate in the production of certain types of pharmaceuticals and agrochemicals.
It is synthesized through a series of chemical reactions that involve the conversion of starting materials into the desired product.
The synthetic routes of PUR131 can be broadly classified into two categories: chemical routes and biochemical routes.

Chemical routes involve the use of chemical reactions to synthesize PUR131.
The most commonly used chemical route involves the esterification of (1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxyamine with phenol in the presence of an acid catalyst.
The reaction involves the deprotection of the methyl group to yield the corresponding phenoxy acid, followed by esterification with phenol.

Another chemical route involves the synthesis of PUR131 through the reaction of (1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxyamine with chloroacetic acid to yield the corresponding monochloride, followed by esterification with phenol.

Biochemical routes involve the use of microorganisms or enzymes to synthesize PUR131.
This approach typically involves the use of bacteria or yeast that are genetically engineered to produce the desired compound.
One example of a biochemical route involves the expression of the gene for (1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxyamine in E.
coli, followed by esterification with phenol.

The choice of synthetic route depends on various factors, including the cost, efficiency, and availability of starting materials and equipment.
Chemical routes are generally more cost-effective and efficient than biochemical routes, especially when large quantities of the product are required.
However, biochemical routes can be more environmentally friendly and may offer advantages in terms of purity and selectivity.

In conclusion, PUR131 can be synthesized through a variety of synthetic routes, including chemical and biochemical routes.
The choice of route depends on various factors, including cost, efficiency, and environmental considerations.
Regardless of the route used, the synthesis of PUR131 requires careful attention to detail and a thorough understanding of the underlying chemical reactions involved.