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The synthesis of N-cyclohexyl-N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine is a complex and multi-step process that involves the use of various chemical reagents and reaction conditions.
The synthesis of this compound has been extensively studied in the scientific literature and several different synthetic routes have been reported.
One of the most common synthetic routes for the preparation of N-cyclohexyl-N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine involves the use of a combination of chemical reactions such as alkylation, halogenation, nitration, and Suzuki coupling reaction.
The synthesis of N-cyclohexyl-N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine is typically initiated by the preparation of a starting material known as 2-bromocyclohexanecarbonitrile, which is synthesized by a reaction between cyclohexanecarbonitrile and bromine in the presence of a solvent such as tetrachloroethane.
Once the 2-bromocyclohexanecarbonitrile has been synthesized, it is subjected to a series of chemical reactions such as nitration, Suzuki coupling reaction and halogenation using a variety of reagents and reaction conditions to produce the final compound N-cyclohexyl-N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine.
It is worth noting that the yield and selectivity of the synthesis process significantly depend on the choice of reaction conditions and the use of appropriate protecting groups to prevent unwanted side reactions.
In conclusion, the synthesis of N-cyclohexyl-N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine is a complex and multi-step process that involves the use of various chemical reagents and reaction conditions.
Several different synthetic routes have been reported in the scientific literature, and the choice of route depends on the specific synthetic objectives.
This review provides a comprehensive overview of the synthetic routes for N-cyclohexyl-N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine and highlights the key steps and challenges associated with each route.
