The Synthetic Routes of METHYL 6-OXO-1,6-DIHYDROPYRIDAZINE-3-CARBOXYLATE

Methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate is an important intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other chemical products.
The synthesis of this compound has been the subject of extensive research in the chemical industry, and several synthetic routes have been developed over the years.

One of the most commonly used synthetic routes involves the reaction of methyl iodide with 6-bromo-1,6-dihydropyridazine-3-carboxylate in the presence of a Lewis acid catalyst, such as aluminum chloride.
The reaction results in the formation of the desired methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate, along with the corresponding bromide ion.
This route is relatively straightforward and can be easily scaled up for industrial production.

Another synthetic route involves the reaction of methyl acetate with 1,6-dihydro-6-oxo-pyridazine-3-carboxylate in the presence of a strong base, such as sodium hydroxide.
The reaction results in the formation of the desired methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate, along with the corresponding acetate ion.
This route is also relatively straightforward and can be easily scaled up for industrial production.

A third synthetic route involves the reaction of methyl chloride with 6-aminomethyl-1,6-dihydro-pyridazine-3-carboxylate in the presence of a Lewis acid catalyst, such as aluminum chloride.
The reaction results in the formation of the desired methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate, along with the corresponding chloride ion.
This route is also relatively straightforward and can be easily scaled up for industrial production.

In addition to the above-mentioned synthetic routes, there are several other methods that have been reported in the literature for the synthesis of methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate.
These include the use of microwave irradiation, the reaction of methyl sulfate with 6-bromo-1,6-dihydro-pyridazine-3-carboxylate, and the reaction of methyl isocyanate with 1,6-dihydro-6-oxo-pyridazine-3-carboxylate.

Overall, the synthetic routes for methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate are diverse and can be adapted to suit different industrial production processes.
The selection of a particular synthetic route will depend on various factors, such as the cost and availability of raw materials, the desired yield and purity of the product, and the scale of production.
Regardless of the synthetic route used, the final product can be purified and isolated using conventional techniques, such as crystallization, filtration, and chromatography.

In conclusion, methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate is an important intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other chemical products, and several synthetic routes have been developed for its synthesis in the chemical industry.
These routes can be adapted to suit different industrial production processes and can be scaled up for large-scale production.
The selection of a particular synthetic route will depend on various factors, such as the cost and availability of raw materials, the desired yield and purity of the product, and the scale of production.