The Synthetic Routes of Imidazo[1,2-b]pyridazine-2-carboxylic acid (9CI)

The Synthetic Routes of Imidazo[1,2-b]pyridazine-2-carboxylic acid (9CI) in the Chemical Industry

Imidazo[1,2-b]pyridazine-2-carboxylic acid (9CI) is an important organic compound with a wide range of applications in the chemical industry.
It is used as a building block for the synthesis of various industrial chemicals, pharmaceuticals, and agrochemicals.
The synthesis of 9CI involves several steps, and the choice of synthetic route depends on the availability of starting materials, the desired yield, and the cost of the process.
In this article, we will discuss the different synthetic routes of 9CI in the chemical industry.

One of the most common methods of synthesizing 9CI is through the reaction of 2-amino-1,3-benzoxazepine with chloroform in the presence of sodium hydroxide.
The reaction results in the formation of N-chloramine, which is then reduced to N-aminomethylidene by hydrogenation in the presence of a catalyst.
The final step involves the decarboxylation of the N-aminomethylidene derivative to yield 9CI.

Another synthetic route involves the reaction of 2-aminopyridine with bromoacetamide in the presence of triethylamine.
The reaction results in the formation of 2-bromo-1,3-oxazepine, which is then hydrolyzed to yield 2-amino-1,3-oxazepine.
The latter is then reacted with chloroform and sodium hydroxide to yield 9CI.

A third synthetic route involves the reaction of 2-aminopyridine with iodomethane in the presence of triethylamine.
The reaction results in the formation of 2-iodo-1,3-oxazepine, which is then hydrolyzed to yield 2-amino-1,3-oxazepine.
The latter is then reacted with chloroform and sodium hydroxide to yield 9CI.

The choice of synthetic route will depend on the availability of starting materials, the desired yield, and the cost of the process.
The three routes outlined above are some of the most common methods of synthesizing 9CI, but there are also other methods that have been reported in the literature.

In conclusion, the synthetic routes of imidazo[1,2-b]pyridazine-2-carboxylic acid (9CI) in the chemical industry are varied and depend on the availability of starting materials, the desired yield, and the cost of the process.
The three routes outlined above are some of the most common methods of synthesizing 9CI, but there are also other methods that have been reported in the literature.
Regardless of the route chosen, 9CI is an important building block for the synthesis of various industrial chemicals, pharmaceuticals, and agrochemicals, and its synthesis continues to be an active area of research in the chemical industry.