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The Chemical Industry is one of the most important industries in the world, as it provides the raw materials and intermediate products for a wide range of other industries, such as pharmaceuticals, plastics, and textiles.
One of the most important compounds in this industry is ETHYL-4-PHENYL PYRIMIDINE-5-CARBOXYLATE, which is used as an intermediate in the production of various pharmaceuticals, herbicides, and other chemical products.
In this article, we will discuss the synthetic routes of ETHYL-4-PHENYL PYRIMIDINE-5-CARBOXYLATE, which is commonly used as an intermediate in the production of the antibiotic AMOXIL and the herbicides DSMA and ROUNDUP.
One of the most commonly used methods for the synthesis of ETHYL-4-PHENYL PYRIMIDINE-5-CARBOXYLATE is the synthesis of N-[(1S)-1-(diethylamino)-3-(4-nitrophenyl)propanamido]-N-(2,2,2-trifluoroethyl)-4-oxo-4H-pyrimidin-2-carboxylate, which is then reduced to the desired compound.
The synthesis of N-[(1S)-1-(diethylamino)-3-(4-nitrophenyl)propanamido]-N-(2,2,2-trifluoroethyl)-4-oxo-4H-pyrimidin-2-carboxylate involves several steps, including the synthesis of the intermediate N-[(1S)-1-(diethylamino)-3-(4-nitrophenyl)propanamido]-N-(2,2,2-trifluoroethyl)amide, which is then treated with a strong acid to form the carboxylate.
The synthesis of N-[(1S)-1-(diethylamino)-3-(4-nitrophenyl)propanamido]-N-(2,2,2-trifluoroethyl)amide involves the reaction of N-((1S)-1-(diethylamino)-3-(4-nitrophenyl)propanamide with N-(2,2,2-trifluoroethyl)chloride in the presence of a strong acid catalyst, such as sulfuric acid.
The synthesis of N-((1S)-1-(diethylamino)-3-(4-nitrophenyl)propanamide involves several steps, including the synthesis of 3-(4-amino-phenyl)-N-((1S)-1-(diethylamino)-propanamide)diacetate, which is then hydrolyzed to the desired compound.
The synthesis of 3-(4-amino-phenyl)-N-((1S)-1-(diethylamino)-propanamide)diacetate involves the reaction of N-((1S)-1-(diethylamino)-propanamide) with 3-bromo-4-nitrophenyl chloride in the presence of a catalyst, such as tributylphosphine, and then diacetylated using acetic anhydride.
The synthesis of N-((1S)-1-(diethylamino)-3-(4-nitrophenyl)propanamide) involves the reduction of N-((1S)-1-(diethylamino)-3-(4-nitrophenyl)propanamide)diacetate using a reducing agent, such as lithium aluminum hydride.
Overall, the synthesis of ETHYL-4-PHENYL PYRIMIDINE-5-CARBOXYLATE is a
