The Synthetic Routes of Bis(4-biphenylyl)amine

Bis(4-biphenylyl)amine, also known as 4,4′-diaminodibenzyl, is a commonly used compound in the chemical industry.
It is used in a variety of applications, including as a precursor to dyes, drugs, and other chemicals.
There are several synthetic routes that can be used to synthesize bis(4-biphenylyl)amine, each with its own advantages and disadvantages.

One common synthetic route for bis(4-biphenylyl)amine involves the reaction of 4-biphenylamine hydrochloride with sodium hydride in the presence of a solvent such as DMF or DMA.
This reaction involves the nucleophilic substitution of the amine group in 4-biphenylamine with the sodium hydride ion, followed by dehydration to remove the hydrogen chloride.
This route is relatively straightforward and can be easily scaled up for industrial production.

Another synthetic route involves the reaction of 4-bromobiphenyl with a strong base such as sodium hydroxide in water.
This reaction involves the substitution of the bromine atom with the amine group in 4-bromobiphenyl, followed by dehydrobromination to remove the bromine.
This route is also relatively straightforward and can be easily scaled up for industrial production.

There are also several other synthetic routes that can be used to synthesize bis(4-biphenylyl)amine, including the reduction of 4,4′-dibromobiphenyl with lithium aluminum hydride, the reaction of 4-biphenylamine with excess sodium hydride in the presence of a solvent such as NMP or DMA, and the reaction of 4-biphenylamine with a strong base such as sodium hydroxide in the presence of an acid catalyst.
Each of these routes has its own advantages and disadvantages, and the choice of route will depend on the specific requirements of the application.

Overall, the synthesis of bis(4-biphenylyl)amine is a well-established synthetic route in the chemical industry, and there are several effective methods for its synthesis.
These methods can be easily scaled up for industrial production and can be used to produce high-quality bis(4-biphenylyl)amine for a variety of applications.