The Synthetic Routes of 6-Oxo-1(6H)-pyridazineacetic acid

6-Oxo-1(6H)-pyridazineacetic acid, also known as pyridine-2,5-dicarboxylic acid, is an organic compound with a unique chemical structure and properties.
It has been widely used in various industries, including the pharmaceutical, agricultural, and chemical industries.
The compound is synthesized through several different routes, each with its own advantages and disadvantages.
In this article, we will discuss the synthetic routes of 6-Oxo-1(6H)-pyridazineacetic acid and their applications in the chemical industry.

1. Hydrolysis of Pyridine-2,5-dicarboxaldehyde

Pyridine-2,5-dicarboxaldehyde is an intermediate in the synthesis of 6-Oxo-1(6H)-pyridazineacetic acid.
The compound is synthesized through the reduction of pyridine-2,5-dione using various reducing agents, such as lithium aluminum hydride (LiAlH4) or hydrogen in the presence of a catalyst, such as palladium on barium sulfate.
The hydrolysis of pyridine-2,5-dicarboxaldehyde using water and a base, such as sodium hydroxide, can also be used to synthesize 6-Oxo-1(6H)-pyridazineacetic acid.
The synthesis of 6-Oxo-1(6H)-pyridazineacetic acid through hydrolysis of pyridine-2,5-dicarboxaldehyde is relatively simple and cost-effective.

2. Decarboxylation of 2-Amino-5-pyridinecarboxylic acid

2-Amino-5-pyridinecarboxylic acid can be synthesized through the condensation of pyridine and glycolic acid using various condensation reagents, such as dicyclohexylcarbodiimide (DCC) or hydrochloric acid.
The compound can then be converted to 2-amino-5-pyridinecarboxylic acid by heating it with a base, such as sodium hydroxide.
The decarboxylation of 2-amino-5-pyridinecarboxylic acid using a strong acid, such as hydrochloric acid, can also be used to synthesize 6-Oxo-1(6H)-pyridazineacetic acid.
The synthesis of 6-Oxo-1(6H)-pyridazineacetic acid through decarboxylation of 2-amino-5-pyridinecarboxylic acid is a relatively efficient method, and the compound can be obtained in high yield.

3. Cyclization of 2-Aminopyridine-5-carboxylic acid

2-Aminopyridine-5-carboxylic acid can be synthesized through the condensation of pyridine and malonic acid using various condensation reagents, such as DCC or hydrochloric acid.
The compound can then be converted to 6-Oxo-1(6H)-pyridazineacetic acid by heating it with a strong acid, such as hydrochloric acid, or by treating it with a base, such as sodium hydroxide.
The cyclization of 2-Aminopyridine-5-carboxylic acid to 6-Oxo-1(6H)-pyridazineacetic acid is a relatively simple and efficient method, and the compound can be obtained in high yield.

4. Nitration of Pyridine-2,5-dicarboxylic acid

Pyridine-2,5-dicarboxylic acid can be synthesized through the condensation of py