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6-Methyl-3-pyridazinemethanamine is an important organic compound that finds application in various industries such as pharmaceuticals, agrochemicals, and dyestuffs.
It is an intermediate in the synthesis of various drugs and pesticides.
In this article, we will discuss the synthetic routes of 6-methyl-3-pyridazinemethanamine.
- Hydrolysis of N-benzyl-N-(2-methoxyphenyl) acetamide:
The first synthetic route to 6-methyl-3-pyridazinemethanamine involves the hydrolysis of N-benzyl-N-(2-methoxyphenyl) acetamide.
This transformation involves the cleavage of the amide bond in N-benzyl-N-(2-methoxyphenyl) acetamide using hydrolytic conditions to afford 6-methyl-3-pyridazinemethanamine.
- Reduction of N-(2-chloro-6-methyl-pyridazin-3-yl)-acetamide:
Another synthetic route to 6-methyl-3-pyridazinemethanamine involves the reduction of N-(2-chloro-6-methyl-pyridazin-3-yl)-acetamide.
This transformation involves the reduction of the nitro group in N-(2-chloro-6-methyl-pyridazin-3-yl)-acetamide using reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogen in the presence of a catalyst such as palladium on barium sulfate to afford 6-methyl-3-pyridazinemethanamine.
- Deaminization of 2-amino-5-methyl-pyridine:
The third synthetic route to 6-methyl-3-pyridazinemethanamine involves the deaminization of 2-amino-5-methyl-pyridine.
This transformation involves the conversion of 2-amino-5-methyl-pyridine into 6-methyl-3-pyridazinemethanamine using deaminizing conditions such as the action of a strong base such as sodium hydroxide or potassium hydroxide.
In conclusion, 6-methyl-3-pyridazinemethanamine is an important organic compound that can be synthesized by various synthetic routes.
These routes include the hydrolysis of N-benzyl-N-(2-methoxyphenyl) acetamide, reduction of N-(2-chloro-6-methyl-pyridazin-3-yl)-acetamide, and deaminization of 2-amino-5-methyl-pyridine.
The selection of the synthetic route depends on the availability of the starting materials, the desired yield, and the cost of the reaction.
The synthetic routes described in this article are used in the industrial synthesis of 6-methyl-3-pyridazinemethanamine, which is an important intermediate in the synthesis of various drugs and pesticides.
