The Synthetic Routes of 6-CHLORO-N4,N4-DIETHYLPYRIMIDINE-2,4-DIAMINE

6-Chloro-N4,N4-diethylpyrimidine-2,4-diamine is an important chemical intermediate that is used in the production of various pharmaceuticals, dyes, and other chemical products.
The synthesis of this compound can be achieved through several different routes, including synthetic and chemical methods.

One of the most commonly used synthetic routes for the synthesis of 6-chloro-N4,N4-diethylpyrimidine-2,4-diamine is the Horner-Wadsworth-Emmons (HWE) reaction.
This reaction involves the use of a metal ion, such as cesium or sodium, and a halogenating agent, such as chlorine, to convert an aryl diazo compound into a dihalogenated derivative.
The product can then be further transformed into the desired diamine through a series of chemical reactions.

Another synthetic route for the synthesis of 6-chloro-N4,N4-diethylpyrimidine-2,4-diamine is the Suzuki reaction.
This reaction involves the use of a palladium catalyst and a boronic acid derivative to convert an aryl halide into an aryl boride.
The aryl boride can then be reacted with an amine, such as N,N-dimethyl ethylamine, to produce the desired diamine.

Chemical routes for the synthesis of 6-chloro-N4,N4-diethylpyrimidine-2,4-diamine are also commonly used.
One such route involves the reduction of N4,N4-bis(chloromethyl)oxamide to produce the desired diamine.
This reduction can be achieved through various chemical processes, including hydrogenation and catalytic reduction.

Another chemical route for the synthesis of 6-chloro-N4,N4-diethylpyrimidine-2,4-diamine involves the reaction of N4,N4-dibutylanthranilate with chloroform to produce the desired diacetamide.
This diacetamide can then be reduced to produce the desired diamine through a series of chemical reactions.

Overall, the synthesis of 6-chloro-N4,N4-diethylpyrimidine-2,4-diamine is a complex process that can be achieved through various synthetic and chemical routes.
The selection of a particular route will depend on various factors, including the availability of starting materials, the desired yield and purity of the product, and the cost and scalability of the process.

In conclusion, the synthetic routes of 6-chloro-N4,N4-diethylpyrimidine-2,4-diamine are numerous and varied.
These routes include the Horner-Wadsworth-Emmons reaction, the Suzuki reaction, and various chemical reduction processes.
The selection of a particular route will depend on a variety of factors, including the availability of starting materials and the desired product characteristics.
Regardless of the route used, the synthesis of 6-chloro-N4,N4-diethylpyrimidine-2,4-diamine is an important synthetic target in the chemical industry.