The Synthetic Routes of 5-Bromo-1-(2-pyrimidinyl)-1H-pyrazole-4-carbonitrile

The synthesis of chemical compounds is a critical component of the chemical industry, which involves the conversion of raw materials into various useful chemical products.
The synthesis of 5-bromo-1-(2-pyrimidinyl)-1H-pyrazole-4-carbonitrile, a organic compound with a unique structure and properties, has been the focus of extensive research in the chemical industry.
The compound is of great interest due to its potential use in various applications, such as in the development of new drugs, agrochemicals, and materials.

Synthetic routes to 5-bromo-1-(2-pyrimidinyl)-1H-pyrazole-4-carbonitrile

There are several synthetic routes to 5-bromo-1-(2-pyrimidinyl)-1H-pyrazole-4-carbonitrile, which can be broadly classified into four categories: direct synthesis, intermediate-mediated synthesis, hydrolysis of N-bromosuccinimide ester, and reduction of N-bromosuccinimide ester.

Direct synthesis

The direct synthesis of 5-bromo-1-(2-pyrimidinyl)-1H-pyrazole-4-carbonitrile involves the coupling of 2-pyrimidineamine with 1-H-pyrazole-4-carbonitrile in the presence of a suitable coupling agent, such as dicyclohexylcarbodiimide (DCC) or hydroxybenzotriazole (HOBT).
This route is relatively straightforward and simple, but the yield of the desired product can be low due to the instability of the intermediate and the optimum conditions required for the reaction.

Intermediate-mediated synthesis

The intermediate-mediated synthesis of 5-bromo-1-(2-pyrimidinyl)-1H-pyrazole-4-carbonitrile involves the synthesis of an intermediate, such as N-bromosuccinimide ester or N-chlorosuccinimide ester, which is then reduced or hydrolyzed to yield the desired product.
This route is more efficient and can provide higher yields of the desired product, but requires the use of toxic and hazardous reagents, such as N-bromosuccinimide, and requires careful handling and disposal.

Hydrolysis of N-bromosuccinimide ester

The hydrolysis of N-bromosuccinimide ester is an alternative synthetic route to 5-bromo-1-(2-pyrimidinyl)-1H-pyrazole-4-carbonitrile.
This route involves the synthesis of N-bromosuccinimide ester, which is then hydrolyzed under basic conditions to yield the desired product.
This route is relatively simple and efficient, but requires the use of toxic and hazardous reagents, such as N-bromosuccinimide, and requires careful handling and disposal.

Reduction of N-bromosuccinimide ester

The reduction of N-bromosuccinimide ester is another alternative synthetic route to 5-bromo-1-(2-pyrimidinyl)-1H-pyrazole-4-carbonitrile.
This route involves the synthesis of N-bromosuccinimide ester, which is then reduced under optimal conditions to yield the desired product.
This route is relatively straightforward and efficient, but requires the use of toxic and hazardous reagents, such as N-bromosuccinimide, and requires careful handling and disposal.

Advantages and disadvantages of the synthetic routes

Each of the synthetic routes to 5-bromo-1-(2-