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4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE is a chemical compound that has various applications in the chemical industry.
This compound is used as an intermediate in the production of various chemicals, pharmaceuticals, and agrochemicals.
The synthetic routes of 4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE are many, and each route has its own advantages and disadvantages.
One of the most common synthetic routes of 4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE is through the reaction of 4-bromo-N-[2-(TBDMSO)ethyl]aniline with benzenesulfonyl chloride in the presence of a base such as triethylamine.
This reaction is exothermic and requires careful handling.
The reaction mixture is then treated with sodium bicarbonate solution to remove the excess bromide ions, and the resulting product is extracted with a solvent such as ether.
The organic layer is then dried over anhydrous sodium sulfate and filtered.
The solvent is then removed under reduced pressure, and the residue is recrystallized using a appropriate solvent to obtain pure 4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE.
Another synthetic route to 4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE is through the reaction of 4-bromo-N-[2-(TBDMSO)ethyl]aniline with benzenesulfonyl chloride in the presence of a coupling agent such as 1,3-dimethyl-3,4,5,6-tetrahydro-2H-pyrimidin-2-one (DMA).
This reaction is also exothermic and requires careful handling.
The reaction mixture is then treated with sodium bicarbonate solution to remove the excess bromide ions, and the resulting product is extracted with a solvent such as ether.
The organic layer is then dried over anhydrous sodium sulfate and filtered.
The solvent is then removed under reduced pressure, and the residue is recrystallized using a appropriate solvent to obtain pure 4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE.
A third synthetic route to 4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE is through the reaction of 4-bromo-N-[2-(TBDMSO)ethyl]aniline with benzenesulfonyl chloride in the presence of a solvent such as N,N-dimethylformamide (DMF).
This reaction is also exothermic and requires careful handling.
The reaction mixture is then treated with sodium bicarbonate solution to remove the excess bromide ions, and the resulting product is extracted with a solvent such as ether.
The organic layer is then dried over anhydrous sodium sulfate and filtered.
The solvent is then removed under reduced pressure, and the residue is recrystallized using a appropriate solvent to obtain pure 4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE.
In conclusion, 4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE is a versatile
