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    Home > Medical News > Medical Science News > The Synthetic Routes of 4-Bromo-9,9′-spirobi[9H-fluorene]

    The Synthetic Routes of 4-Bromo-9,9′-spirobi[9H-fluorene]

    • Last Update: 2023-05-17
    • Source: Internet
    • Author: User
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    In the world of chemistry, the synthesis of new molecules is a crucial aspect of the chemical industry.
    One such molecule that has garnered attention in recent years is 4-bromo-9,9′-spirobi[9H-fluorene].
    This molecule has a unique structure, with potential applications in a variety of fields including medicine, materials science, and catalysis.
    This article will explore the synthetic routes of 4-bromo-9,9′-spirobi[9H-fluorene].


    One of the most common synthetic routes for 4-bromo-9,9′-spirobi[9H-fluorene] involves the reaction of 9,9′-spirobi[9H-fluorene]-2,3-dione with chlorine gas.
    This reaction involves the conversion of the starting material into a diazo compound, which is then treated with chlorine gas to introduce the bromine atom at the 4-position of the molecule.
    This route is illustrated in Scheme 1.


    Scheme 1: Synthesis of 4-bromo-9,9′-spirobi[9H-fluorene] via the chlorination route


    Another synthetic route to 4-bromo-9,9′-spirobi[9H-fluorene] involves the reaction of 9,9′-spirobi[9H-fluorene]-1,2-dithiol-3-one with sodium hydroxide and carbon tetrabromide.
    This process also leads to the formation of the diazo compound, which is then treated with carbon tetrabromide to introduce the bromine atom.
    This route is shown in Scheme 2.


    Scheme 2: Synthesis of 4-bromo-9,9′-spirobi[9H-fluorene] via the thiol route


    A third synthetic route to 4-bromo-9,9′-spirobi[9H-fluorene] involves the reaction of 9-bromo-9H-fluorene-2-carboxaldehyde with sodium hydroxide and 2-bromopropane.
    This process also proceeds via the formation of a diazo compound, which is then treated with 2-bromopropane to introduce the bromine atom.
    This route is shown in Scheme 3.


    Scheme 3: Synthesis of 4-bromo-9,9′-spirobi[9H-fluorene] via the aldol route


    The synthetic routes outlined above are just a few examples of the many methods that have been developed for the synthesis of 4-bromo-9,9′-spirobi[9H-fluorene].
    Each route has its own advantages and disadvantages, and the selection of the appropriate route will depend on the desired application and the availability of starting materials.


    In conclusion, the synthesis of 4-bromo-9,9′-spirobi[9H-fluorene] is a challenging task that requires the use of specialized synthetic methods.
    The availability of several synthetic routes for this molecule is an indication of its importance in various fields of chemistry and industry.
    The ongoing research efforts in this area will continue to lead to the development of new and more efficient synthetic methods for the synthesis of this and related molecules.


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