The Synthetic Routes of 4-Amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione

4-Amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione is an organic compound that has recently gained attention in the chemical industry due to its unique properties and potential applications.
This compound can be synthesized through various routes, and each synthetic route has its own advantages and disadvantages.
In this article, we will discuss some of the synthetic routes of 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione and their applications in the chemical industry.

One of the most common synthetic routes for 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione is the direct reaction of malononitrile with ammonia in the presence of a catalyst, such as cesium carbonate or triethylamine.
This route is simple and efficient, and it uses readily available starting materials.
The reaction is carried out in a solvent, such as acetonitrile or DMF, and the product can be purified by recrystallization or column chromatography.
This synthetic route has been widely used in the industry, as it is simple and cost-effective.

Another synthetic route for 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione involves the reaction of 2-amino-5-methylthiophene-3-carboxaldehyde with 6-chloro-7-fluoro-4-oxo-1,8-naphthyridine-2,1(3H,5H)-dione in the presence of a catalyst, such as sodium hydroxide or triethylamine.
This route is also simple and efficient, and it uses readily available starting materials.
The reaction is carried out in a solvent, such as DMF or DMA, and the product can be purified by recrystallization or column chromatography.
This synthetic route has also been widely used in the industry, as it is simple and cost-effective.

A third synthetic route for 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione involves the reaction of 2-amino-3-methylthiophene-4-carboxaldehyde with 6-chloro-7-fluoro-4-oxo-1,8-naphthyridine-2,1(3H,5H)-dione in the presence of a catalyst, such as sodium hydroxide or triethylamine.
This route is similar to the previous route, but it uses a different starting material.
The reaction is carried out in a solvent, such as DMF or DMA, and the product can be purified by recrystallization or column chromatography.
This synthetic route has also been widely used in the industry, as it is simple and cost-effective.

In addition to the above-mentioned synthetic routes, other routes to 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione have also been reported, such as the reaction of 2-amino-5-methylthiophene with 6-chloro-7-fluoro-4-oxo-1,8-naphthyridine in the presence of a catalyst, such as sodium hydroxide or hydrochloric acid.

In conclusion, there are several synthetic routes to 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6