The Synthetic Routes of (4,6-dichloropyrimidin-5-yl)methanol

(4,6-dichloropyrimidin-5-yl)methanol, also known as 4,6-dichloropyrimidine methanol, is a compound that is commonly used as an intermediate in the production of various chemicals, pharmaceuticals, and agrochemicals.
The synthetic routes for this compound can vary depending on the desired product and the starting materials available.

One common synthetic route for (4,6-dichloropyrimidin-5-yl)methanol involves the reaction of chloroform with formaldehyde and a base such as sodium hydroxide.
The reaction produces (4-chloroformylphenyl)methanol, which is then converted to (4,6-dichloropyrimidin-5-yl)methanol through a series of chemical reactions.
This route is shown below:

CHCl3 + CH2O + NaOH → (4-chloroformylphenyl)methanol
(4-chloroformylphenyl)methanol → (4,6-dichloropyrimidin-5-yl)methanol

Another synthetic route for (4,6-dichloropyrimidin-5-yl)methanol involves the reaction of 4-bromo-6-chloropyrimidine with a base such as sodium hydroxide to form the corresponding sodium salt.
The sodium salt is then treated with methanol to produce (4,6-dichloropyrimidin-5-yl)methanol.
This route is shown below:

4-bromo-6-chloropyrimidine + NaOH → (4-chloroformylphenyl)methanol
(4-chloroformylphenyl)methanol + Methanol → (4,6-dichloropyrimidin-5-yl)methanol

A third synthetic route involves the reaction of 4-chloro-6-fluoropyrimidine with sodium hydroxide to form the corresponding sodium salt.
The sodium salt is then treated with methanol and a base such as potassium hydroxide to form (4,6-dichloropyrimidin-5-yl)meth