The Synthetic Routes of 3-Pyridinamine,2,6-difluoro-(9CI)

3-Pyridinamine, 2,6-difluoro-(9CI) is a compound that belongs to the organic molecule family and is commonly used in the pharmaceutical and agrochemical industries.
It is an important intermediate for the synthesis of various drugs and pesticides.
In the chemical industry, the synthesis of this compound can be achieved through several different methods, including synthetic routes.

One of the most commonly used synthetic routes for the synthesis of 3-pyridinamine, 2,6-difluoro-(9CI) is the Hofmann reaction.
This reaction involves the treatment of cyanamide with zinc amalgam in the presence of an organic solvent such as ether or benzene.
The reaction produces 2,6-difluoro-3-pyridinecarboxaldehyde, which can then be converted into the desired product through further chemical transformations.

Another synthetic route for the synthesis of 3-pyridinamine, 2,6-difluoro-(9CI) involves the use of the Williamson ether synthesis.
This reaction involves the treatment of an alcohol with a halogen in the presence of a Lewis acid catalyst.
In this case, the alcohol used is 2-fluoro-1-propanol, and the halogen is bromine.
The reaction produces 1,2-difluoro-3-propanol, which can then be converted into the desired product through further chemical transformations.

A third synthetic route for the synthesis of 3-pyridinamine, 2,6-difluor-(9CI) involves the use of the Cannizzaro reaction.
This reaction involves the disproportionation of an aldehyde into a carboxylic acid and an alcohol.
In this case, the aldehyde used is 2,6-difluoro-3-pyridinecarboxaldehyde, which is obtained through the Hofmann reaction.
The reaction produces 2,6-difluoro-3-pyridinecarboxylic acid and 2-fluoro-1-propanol, which can then be converted into the desired product through further chemical transformations.

The choice of synthetic route for the synthesis of 3-pyridinamine, 2,6-difluoro-(9CI) depends on several factors, including the availability of starting materials, the cost of the reaction, and the desired product.
The Hofmann reaction is a commonly used synthetic route due to the availability of starting materials and the relatively low cost of the reaction.
The Williamson ether synthesis and the Cannizzaro reaction are also viable synthetic routes that can be used depending on the desired product and the availability of starting materials.

In conclusion, the synthetic routes for the synthesis of 3-pyridinamine, 2,6-difluoro-(9CI) are numerous and varied.
The choice of synthetic route depends on several factors, including the availability of starting materials, the cost of the reaction, and the desired product.
The Hofmann reaction is a commonly used synthetic route due to the availability of starting materials and the relatively low cost of the reaction.
The Williamson ether synthesis and the Cannizzaro reaction are also viable synthetic routes that can be used depending on the desired product and the availability of starting materials.