The Synthetic Routes of 3-CHLORO-6-PYRROLIDIN-1-YL-PYRIDAZINE

The synthesis of 3-chloro-6-pyrrolidin-1-yl-pyridazine is an important process in the chemical industry, as this compound has various applications in the production of pharmaceuticals, agrochemicals, and other chemical products.
There are several synthetic routes that can be used to synthesize 3-chloro-6-pyrrolidin-1-yl-pyridazine, each with its own advantages and disadvantages.

One of the most common synthetic routes for 3-chloro-6-pyrrolidin-1-yl-pyridazine involves the reaction of N-[(1S)-1-(3-chlorophenyl)ethyl]-N'-[2-[(6-aminopyridin-3-yl)methyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]urea with sodium hydroxide in the presence of a solvent such as N,N-dimethylformamide (DMF) or N-methyl-2-pyrrolidone (NMP).
This reaction results in the formation of the desired compound after appropriate conditions such as temperature and time.

Another synthetic route for 3-chloro-6-pyrrolidin-1-yl-pyridazine involves the reaction of 3-chlorophenyl acetate with 2-aminopyridine in the presence of a solvent such as acetonitrile or DMF.
This reaction is then followed by hydrolysis of the resulting product using a strong acid such as hydrochloric acid, which leads to the formation of the desired compound.

A third synthetic route for 3-chloro-6-pyrrolidin-1-yl-pyridazine involves the reaction of 3-chlorophenylamine with 6-aminopyridine in the presence of a solvent such as NMP or DMF.
The reaction is then completed by hydrolysis of the resulting product using a strong acid such as hydrochloric acid, which leads to the formation of the desired compound.

Each of these synthetic routes has its own advantages and disadvantages.
For instance, the first route involves the use of harsh chemicals such as sodium hydroxide, which can be hazardous to the environment and human health.
Additionally, the reaction conditions involved in this route are quite severe, which can lead to low yield and high cost of production.

The second route is more environmentally friendly, as it involves the use of less harsh chemicals such as acetonitrile and DMF.
However, the yield of the reaction is relatively low, and the cost of production is also relatively high due to the use of expensive reagents.

The third route is more cost-effective, as it involves the use of less expensive reagents such as NMP and hydrochloric acid.
However, the reaction conditions involved in this route are relatively severe, and the reaction can be time-consuming, leading to lower yield.

Overall, the choice of synthetic route for 3-chloro-6-pyrrolidin-1-yl-pyridazine depends on several factors such as cost, yield, environmental impact, and availability of the necessary reagents.
As the chemical industry continues to evolve, new and more efficient synthetic routes for 3-chloro-6-pyrrolidin-1-yl-pyridazine are likely to be developed, offering improved performance and cost-effectiveness.