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The synthesis of 3-chloro-6-(piperidin-3-ylmethoxy)-pyridazine hydrochloride, with the molecular formula C10H15Cl2N3O and a molecular weight of 264.
15, is an important synthetic route in the chemical industry.
This molecule is a key intermediate in the production of certain pharmaceuticals, agrochemicals, and other chemical products.
There are several synthetic routes to 3-chloro-6-(piperidin-3-ylmethoxy)-pyridazine hydrochloride, each with its own advantages and disadvantages.
The choice of synthetic route depends on various factors such as cost, availability of reagents, and scale of production.
One of the common synthetic routes to this compound involves the reaction of 3-chloro-6-aminopyridazine with methyl iodide and piperidine in the presence of a solvent such as DMF or DMA.
The reaction proceeds through a series of steps, including the formation of an imine intermediate, which is subsequently hydrolyzed to yield the desired product.
Another synthetic route involves the reaction of 3-chloro-6-aminopyridazine with N-methoxy-N-methyl piperazine in the presence of a solvent such as DMSO and a catalytic amount of HCl.
This reaction results in the formation of the desired product after the appropriate workup and purification steps.
Yet another synthetic route involves the reaction of 3-chloro-6-nitropyridazine with N-methoxy-N-methyl piperazine in the presence of a solvent such as DMF and a catalytic amount of DMAP.
The reaction proceeds through a series of steps, including the formation of an imine intermediate, which is subsequently reduced to yield the desired product.
The choice of synthetic route depends on several factors such as cost, availability of reagents, and scale of production.
For example, the first synthetic route is relatively simple and can be performed on a large scale, while the second and third routes are more complex and require more specialized reagents.
The synthetic routes to 3-chloro-6-(piperidin-3-ylmethoxy)-pyridazine hydrochloride are important not only in the production of pharmaceuticals and agrochemicals but also in other applications that require this specific compound.
The properties of this compound make it an ideal building block for the synthesis of other molecules with desirable properties.
In conclusion, the synthetic routes to 3-chloro-6-(piperidin-3-ylmethoxy)-pyridazine hydrochloride are important in the chemical industry, and the choice of synthetic route depends on various factors such as cost, availability of reagents, and scale of production.
The synthetic routes are designed to provide a convenient and cost-effective way to produce this important compound, which is widely used in the production of pharmaceuticals, agrochemicals, and other chemical products.