The Synthetic Routes of (3-chloro-5-fluoropyridin-2-yl)MethanaMine

(3-chloro-5-fluoropyridin-2-yl)Methane, also known as 3-chloro-5-fluoro-2-(methylamino)pyridine, is an important organic compound that finds use in various applications in the chemical industry.
It is commonly used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and other chemicals.
The synthesis of (3-chloro-5-fluoropyridin-2-yl)Methane can be achieved through several different routes, some of which are outlined below.

One of the most commonly used synthetic routes for the preparation of (3-chloro-5-fluoropyridin-2-yl)Methane involves the reaction of 2-chloro-5-fluoropyridine with methylamine in the presence of a strong acid catalyst, such as sulfuric acid.
The reaction leads to the formation of the desired product, along with hydrogen chloride gas and water.
The reaction can be summarized as follows:

2-chloro-5-fluoropyridine + MeNH2 + H2SO4 → 3-chloro-5-fluoropyridin-2-yl)Methane + 2HCl + 2H2O

Another synthesis route for (3-chloro-5-fluoropyridin-2-yl)Methane involves the reaction of 2-chloro-5-fluoropyridine with dimethylamine in the presence of an organic solvent, such as dichloromethane or chloroform.
The reaction is typically catalyzed by a strong acid catalyst, such as sulfuric acid or phosphoric acid.
The reaction leads to the formation of the desired product, along with hydrogen chloride gas and the organic solvent.
The reaction can be summarized as follows:

2-chloro-5-fluoropyridine + 2NMe2 + H2SO4 or H3PO4 → 3-chloro-5-fluoropyridin-2-yl)Methane + 2HCl + 2NMe2 (ORG)

Yet another synthesis route for (3-chloro-5-fluoropyridin-2-yl)Methane involves the reaction of 2-chloro-5-fluoropyridine with 2-methylpiperidine in the presence of a strong acid catalyst, such as sulfuric acid.
The reaction leads to the formation of the desired product, along with hydrogen chloride gas and water.
The reaction can be summarized as follows:

2-chloro-5-fluoropyridine + 2-methylpiperidine + H2SO4 → 3-chloro-5-fluoropyridin-2-yl)Methane + 2HCl + 2H2O

(3-chloro-5-fluoropyridin-2-yl)Methane can also be synthesized through the reaction of 2-chloro-5-fluoropyridine with 2-(methylsulfonyl)acetic acid in the presence of a strong base catalyst, such as sodium hydroxide.
The reaction leads to the formation of the desired product, along with water and methanesulfonic acid.
The reaction can be summarized as follows:

2-chloro-5-fluoropyridine + 2-(methylsulfonyl)acetic acid + NaOH → 3-chloro-5-fluoropyridin-2-yl)Methane + H2O + CH3SO3H

In conclusion, (3-chloro-5-fluoropyridin-2-yl)Meth