-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
3-Amino-5-methylpyridine-2-carbonitrile, also known as 3-aminomethylpyridine-2-carboxylate, is a compound that is used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other chemicals.
It can be synthesized through several different routes, including synthetic routes that involve the use of nitriles, amides, and other reagents.
One of the most common synthetic routes for 3-aminomethylpyridine-2-carboxylate involves the use of nitrile reduction.
This route involves the reduction of a nitrile, such as acetonitrile, using a reducing agent, such as lithium aluminum hydride (LiAlH4), in the presence of a solvent, such as tetrahydrofuran (THF).
The resulting product is then hydrolyzed using a strong acid, such as hydrochloric acid, to produce the desired amide.
Another synthetic route for 3-aminomethylpyridine-2-carboxylate involves the use of an amide synthesis reaction.
This route involves the reaction of an amino acid, such as methylamine, with a carboxylic acid, such as 5-methylpyridine-2-carboxylic acid, in the presence of a condensing agent, such as dicyclohexylcarbodiimide (DCC).
The resulting product is then hydrolyzed using a strong acid, such as hydrochloric acid, to produce the desired amide.
A third synthetic route for 3-aminomethylpyridine-2-carboxylate involves the use of a reductive amination reaction.
This route involves the reaction of an amine, such as methylamine, with a carboxylic acid, such as 5-methylpyridine-2-carboxylic acid, in the presence of a reducing agent, such as sodium cyanoborohydride (NaBH3CN), and a solvent, such as dimethylformamide (DMF).
The resulting product is then hydrolyzed using a strong acid, such as hydrochloric acid, to produce the desired amide.
In conclusion, 3-aminomethylpyridine-2-carboxylate can be synthesized through several different synthetic routes, including nitrile reduction, amide synthesis, and reductive amination reactions.
These routes involve the use of a variety of reagents and solvents, and the resulting product can be further transformed into other pharmaceuticals and chemicals through further synthetic steps.
