-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
3,5-Dichloropyridazin-4-amine is a highly important chemical compound in the pharmaceutical and agrochemical industries.
It is widely used as an intermediate in the synthesis of various drugs, pesticides, and other chemical products.
The synthesis of 3,5-dichloropyridazin-4-amine can be achieved through several synthetic routes, each of which has its own advantages and disadvantages.
One of the most common synthetic routes for 3,5-dichloropyridazin-4-amine involves the reaction of 2-chloropyridine-3-carboxaldehyde with sodium hydroxide followed by condensation with 4-aminopyridine.
This route involves several steps, including the preparation of the starting materials, the reaction steps, and the purification of the product.
Another synthetic route involves the reduction of 2,6-dichloropyridine-3-oxide using hydrogen in the presence of a metal catalyst, such as palladium or platinum.
The reduction process results in the formation of 3,5-dichloropyridazin-4-amine, which can be further purified and used as a starting material in downstream synthetic reactions.
A third synthetic route involves the use of a redox reaction between 2-chloropyridine-3-carboxylate and 4-amino-2,5-dimethoxybenzene in the presence of a solvent and a catalyst.
The reaction produces 3,5-dichloropyridazin-4-amine, which can be purified and used as a starting material in further reactions.
The choice of synthetic route depends on a variety of factors, including the availability and cost of starting materials, the desired yield and purity of the final product, and the compatibility of the reaction conditions with downstream processing steps.
In conclusion, 3,5-dichloropyridazin-4-amine is a highly important intermediate in the synthesis of various pharmaceutical and agrochemical products.
Synthetic routes for the production of 3,5-dichloropyridazin-4-amine include the reaction of 2-chloropyridine-3-carboxaldehyde with sodium hydroxide followed by condensation with 4-aminopyridine, reduction of 2,6-dichloropyridine-3-oxide using hydrogen in the presence of a metal catalyst, and the use of a redox reaction between 2-chloropyridine-3-carboxylate and 4-amino-2,5-dimethoxybenzene in the presence of a solvent and a catalyst.
The choice of synthetic route depends on several factors, including the availability and cost of starting materials, the desired yield and purity of the final product, and the compatibility of the reaction conditions with downstream processing steps.
