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The Synthetic Routes of 2-(Trifluoromethyl)-3-pyridinemethanol

 Last Update: 2023-05-04
 Source: Internet
 Author: User

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2-(Trifluoromethyl)-3-pyridinemethanol, also known as 2-TFP, is a common intermediate in the synthesis of a variety of pharmaceuticals, agrochemicals, and industrial chemicals.
It can be synthesized through several different methods, each with its own advantages and disadvantages.
In this article, we will discuss some of the most commonly used synthetic routes for 2-TFP, and the factors that influence the choice of synthetic route.

One of the most common methods for synthesizing 2-TFP is through the reaction of 2-fluoroacetaldehyde with 3-aminopyridine in the presence of a strong acid catalyst, such as sulfuric acid or phosphoric acid.
This reaction can be carried out at room temperature, and the product can be isol

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