The Synthetic Routes of 2-Chloro-4,6-dimethoxypyrimidine

2-Chloro-4,6-dimethoxypyrimidine is an important synthetic intermediate that finds use in various industrial processes.
It is widely used as an intermediate in the synthesis of drugs, agrochemicals, and other fine chemicals.
The synthesis of 2-chloro-4,6-dimethoxypyrimidine involves several steps, and the route taken to synthesize this compound depends on the desired end product and the starting materials available.

One of the most widely used methods for the synthesis of 2-chloro-4,6-dimethoxypyrimidine is the Hock-Schomburg-type synthesis, which involves the condensation of 2-chloro-4,6-dimethoxy-benzaldehyde with sodium hydroxide to form the corresponding hydrate, followed by hydrolysis to form the acid.
The acid is then neutralized with a strong base, such as sodium hydroxide, and the resulting product is purified by recrystallization.

Another common route to 2-chloro-4,6-dimethoxypyrimidine is the Mitsunobu-type synthesis, which involves the reaction of 4-bromo-2-methyl-6-ethyl-pyrimidine with 2,6-lutidine, sodium hydroxide, and potassium carbonate in the presence of a catalytic amount of zinc iodide.
The resulting product is then purified by recrystallization.

Aldol condensation is another method for the synthesis of 2-chloro-4,6-dimethoxypyrimidine.
This process involves the reaction of 4-methyl-2-nitro-pyrimidine with dimethyl-malonate in the presence of a base, such as sodium hydroxide, and a solvent, such as dimethylformamide.
The resulting product is then purified by recrystallization.

In addition to the above-mentioned methods, 2-chloro-4,6-dimethoxypyrimidine can also be synthesized by the Suzuki-Miyaura coupling reaction, the Heck reaction, and the Stille reaction.
These methods are useful for the synthesis of large quantities of 2-chloro-4,6-dimethoxypyrimidine, and are commonly used in industrial processes.

The synthesis of 2-chloro-4,6-dimethoxypyrimidine is a widely studied area, and many variations and modifications of the above-mentioned methods have been reported in the literature.
The choice of route depends on the desired end product, the availability of starting materials, and the scale of production.

2-Chloro-4,6-dimethoxypyrimidine is an important synthetic intermediate that finds use in the synthesis of drugs, agrochemicals, and other fine chemicals.
Several methods for the synthesis of this compound have been reported, including the Hock-Schomburg-type synthesis, the Mitsunobu-type synthesis, the Aldol condensation, and the Suzuki-Miyaura coupling, the Heck reaction, and the Stille reaction.
The choice of route depends on the desired end product, the availability of starting materials, and the scale of production.