The Synthetic Routes of 2,6-Dichloro-N-cyclopropyl-4-pyrimidinemethanamine

The production of 2,6-dichloro-N-cyclopropyl-4-pyrimidinemethanamine (CDDP) and its synthetic routes have been extensively studied in the chemical industry.
CDDP is an important intermediate in the production of various pharmaceuticals and agrochemicals, and its synthesis has been the subject of much research due to its complexity and the potential difficulties associated with its synthesis.

One of the most commonly used synthetic routes for CDDP is via the Suzuki reaction.
This involves the coupling of a boronic acid derivative with a benzyl halide in the presence of a palladium catalyst.
The resulting product is then treated with a nucleophile, such as ammonia, to form the final product.

Another commonly used synthetic route for CDDP is via the Stille reaction.
This involves the coupling of a boronic acid derivative with a phenyl acetylene in the presence of a palladium catalyst.
The resulting product is then treated with a base to form the final product.

These synthetic routes have been widely adopted in the chemical industry due to their relative ease and high yield.
However, they can also be associated with some difficulties such as high cost of palladium catalyst and the need for strict control of reaction conditions.

There are also other synthetic routes that have been reported in literature, such as the use of microwave irradiation, Copper (I) iodide, or hydrogenation, but these methods have not been widely adopted due to their limited yield or higher cost.

In addition to the synthetic routes, the production of CDDP also involves several steps such as purification and isolation, which can also have a significant impact on the overall cost and efficiency of the process.
These steps can involve the use of various purification methods such as crystallization, filtration, and chromatography, which can also have an impact on the yield and purity of the final product.

Overall, the production of CDDP continues to be a subject of research and development in the chemical industry due to its importance as an intermediate in the production of various pharmaceuticals and agrochemicals.
The adoption of new and more efficient synthetic routes, as well as the development of new purification methods, is expected to have a significant impact on the cost and efficiency of CDDP production in the future.