The Synthetic Routes of 2,4-DIMETHOXY-5-PYRIMIDINECARBOXYLIC ACID

2,4-Dihydroxypyridine carboxylic acid, also known as 2,4-dimethoxy-5-pyrimidinecarboxylic acid, is a synthetic chemical compound with a distinctive odor.
It is commonly used as a building block in the synthesis of other chemicals, and has a wide range of applications in the fields of pharmaceuticals, agrochemicals, and dyes.

The synthesis of 2,4-dihydroxypyridine carboxylic acid can be achieved through several different routes, including the following:

1. Hydrolysis of N-methyl-2,4-dibenzyloxyphenylamine
   One of the most common methods of synthesizing 2,4-dihydroxypyridine carboxylic acid is by the hydrolysis of N-methyl-2,4-dibenzyloxyphenylamine.
   This method involves reacting N-methyl-2,4-dibenzyloxyphenylamine with a strong acid, such as hydrochloric acid or sulfuric acid, to generate the diacid derivative.
   The diacid is then hydrolyzed using a base, such as sodium hydroxide, to yield the desired product.
   
2. Condensation of salicylaldehyde with 2,4-dimethoxy-6-methyl-pyridine
   Another method of synthesizing 2,4-dihydroxypyridine carboxylic acid is through the condensation of salicylaldehyde with 2,4-dimethoxy-6-methyl-pyridine.
   This method involves reacting salicylaldehyde with 2,4-dimethoxy-6-methyl-pyridine in the presence of an acid catalyst, such as sulfuric acid.
   The resulting product is then treated with a base, such as sodium hydroxide, to yield the desired diacid derivative.
   
3. Carboxylation of 2-(2,4-dimethoxyphenyl)acetic acid
   A third method of synthesizing 2,4-dihydroxypyridine carboxylic acid is by the carboxylation of 2-(2,4-dimethoxyphenyl)acetic acid.
   This method involves reacting 2-(2,4-dimethoxyphenyl)acetic acid with a carboxylic acid derivative, such as mesitylenesulonic acid or multifunctional anhydrides, in the presence of a metal catalyst, such as zinc or titanium.
   

Overall, the synthesis of 2,4-dihydroxypyridine carboxylic acid can be achieved through a variety of routes, each with its own advantages and disadvantages.
The choice of method will depend on factors such as cost, availability of starting materials, and the desired yield.
Regardless of the method used, 2,4-dihydroxypyridine carboxylic acid continues to be an important building block in the synthesis of a wide range of chemicals and materials.