The Synthetic Routes of 1-PYRIDIN-2-YLMETHYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER

1-PYRIDIN-2-YLMETHYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER: A CHEMICAL COMPOUND WITH MULTIPLE APPLICATIONS

1-Pyridin-2-ylmethylpiperidine-4-carboxylic acid ethyl ester, also known as PP-101, is a synthetic chemical compound that has been widely used in various industries such as pharmaceuticals, agrochemicals, and dyes.
The compound has been synthesized through various synthetic routes, and the choice of route depends on the desired yield, cost, and availability of raw materials.
This article will discuss the three most commonly used synthetic routes for the production of 1-pyridin-2-ylmethylpiperidine-4-carboxylic acid ethyl ester.

Synthetic Route 1: via N-Alkylation of N-Methyl-D-Aspartate with Piperidine

N-alkylation of N-methyl-D-aspartate with piperidine is a commonly used synthetic route for the production of 1-pyridin-2-ylmethylpiperidine-4-carboxylic acid ethyl ester.
The process involves the reaction of N-methyl-D-aspartate with piperidine in the presence of a catalyst such as ribbon-type zinc iodide.
The reaction produces N-methyl-D-aspartate-piperidine adduct, which is then reduced to obtain 1-pyridin-2-ylmethylpiperidine-4-carboxylic acid ethyl ester.

Synthetic Route 2: via N-Alkylation of 1-Methyl-3-piperidin-2-one with Ethyl Bromide

Another commonly used synthetic route for the production of 1-pyridin-2-ylmethylpiperidine-4-carboxylic acid ethyl ester is via N-alkylation of 1-methyl-3-piperidin-2-one with ethyl bromide.
The process involves the reaction of 1-methyl-3-piperidin-2-one with ethyl bromide in the presence of a catalyst such as dimethylformamide.
The reaction produces 1-ethyl-3-piperidin-2-one, which is then reduced to obtain 1-pyridin-2-ylmethylpiperidine-4-carboxylic acid ethyl ester.

Synthetic Route 3: via N-Alkylation of 1-Methylpiperidine-2,4-dione with Ethyl Suberate

The third commonly used synthetic route for the production of 1-pyridin-2-ylmethylpiperidine-4-carboxylic acid ethyl ester is via N-alkylation of 1-methylpiperidine-2,4-dione with ethyl suberate.
The process involves the reaction of 1-methylpiperidine-2,4-dione with ethyl suberate in the presence of a catalyst such as sodium hydride.
The reaction produces 1-ethyl-2,4-piperidinedione, which is then reduced to obtain 1-pyridin-2-ylmethylpiperidine-4-carboxylic acid ethyl ester.

Advantages of 1-Pyridin-2-ylmethylpiperidine-4-carboxylic Acid Ethyl Ester

1-Pyridin-2-ylmethylpiperidine-4-carbox